Evolutionary Biology
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Discovery of the Principal Cystic Fibrosis Mutation (F508del) in Ancient DNA from Iron Age Europeans
The most common, life-threatening autosomal recessive disease of Europeans and Euro-Americans, cystic fibrosis (CF), occurs predominately in patients with the F508del mutation.1 Although F508del is…
Received 29 October 2007 17:17 UTC; Posted 29 October 2007
Posted to: Genetics & Genomics, Evolutionary Biology
Age and origin of enigmatic megaherbs from the subantarctic islands
Biogeographic relationships in the southern hemisphere have puzzled biologists for the last two centuries. Once joined to form the supercontinent Gondwana, Africa, Antarctica, Australia, New Zealan…
Received 28 October 2007 20:54 UTC; Posted 29 October 2007
Posted to: Ecology, Plant Biology, Evolutionary Biology
Estimation of DNA Sequence Context-dependent Mutation Rates Using Primate Genomic Sequences: Application to Estimation of Selection Bias in Protein (Human TP53) Evolution
Understanding of the mechanism of DNA mutation process is critical for studying the functional consequences of genetic variation in clinical medicine (eg. drug response) as well as other complex tr…
Received 19 October 2007 18:28 UTC; Posted 23 October 2007
Posted to: Ecology, Bioinformatics, Evolutionary Biology
EvolveAGene 3: A DNA coding sequence evolution simulation program
EvolveAGene 3 is a realistic coding sequence simulation program that separates mutation from selection and allows the user to set selection conditions, including variable regions of selection inten…
Received 16 October 2007 19:00 UTC; Posted 16 October 2007
Posted to: Ecology, Genetics & Genomics, Bioinformatics, Evolutionary Biology
Treemap Versus BPA (Again): A Response to Dowling
TreeMap is a computer program for analysing host-parasite cospeciation. We respond to Dowling’s (Cladistics, 18: 416-435) recent comparison of TreeMap and Brooks Parsimony Analysis (BPA) by showing…
Received 18 September 2007 09:09 UTC; Posted 18 September 2007
Posted to: Bioinformatics, Evolutionary Biology
On The Dangers Of Aligning RNA Sequences Using “Conserved” Motifs
Aligning RNA sequences can be a challenging task. Automatic sequence alignment programs typically align sequences only with respect to primary sequence, and as a result may yield spurious alignment…
Received 18 September 2007 09:05 UTC; Posted 18 September 2007
Posted to: Bioinformatics, Evolutionary Biology
Towards a Taxonomically Intelligent Phylogenetic Database
This note outlines some of the key intellectual obstacles that stand in the way of creating a usable phylogenetic database. These challenges include the need to accommodate multiple taxonomic names…
Received 18 September 2007 09:01 UTC; Posted 18 September 2007
Posted to: Bioinformatics, Evolutionary Biology
Aggregation of Single Nucleotide Polymorphisms in a Human H5N1 Clade 2.2 Hemagglutinin
The rapid evolution of the H5N1 serotype of avian influenza has been explained by a mechanism involving the selection of single nucleotide polymorphisms generated by copy errors. The recent emerge…
Received 10 September 2007 09:26 UTC; Posted 12 September 2007
Posted to: Genetics & Genomics, Evolutionary Biology
Precise Similarity of Many Human Proteins to Proteins of Prokarya
Proteins originated in early forms of life and have long survived, because they have always been required. Some recognizably similar proteins are found in all sequence comparisons between species…
Received 22 August 2007 22:00 UTC; Posted 23 August 2007
Posted to: Genetics & Genomics, Evolutionary Biology
Systema Naturae. Classification of living things.
Original classification of living organisms containing four kingdoms (Monera, Protista, Vegetabilia and Animalia), 60 phyla and 254 classes, is presented. The classification is based on latest avai…
Received 16 August 2007 22:37 UTC; Posted 17 August 2007
Posted to: Evolutionary Biology
