Developmental Biology
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Off-target response to decoy oligodeoxynucleotide treatment
Background: The transcription factor PAX2 regulates key developmental processes, including mediation of resistance to apoptosis. Inappropriate PAX2 expression has been implicated in facilitating …
Received 10 September 2008 04:24 UTC; Posted 10 September 2008
Posted to: Cancer, Developmental Biology, Molecular Cell Biology
Stress responsive miR-23a attenuates skeletal muscle atrophy by targeting MAFbx /atrogin-1
Muscle atrophy occurs in many pathological states and results primarily from accelerated protein degradation by the ubiquitin-proteasome pathway. We used dexamethasone to induce muscle wasting and …
Received 13 August 2008 02:17 UTC; Posted 15 August 2008
Posted to: Developmental Biology, Molecular Cell Biology
Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution
Although, as their names imply, estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully unders…
Received 12 August 2008 02:08 UTC; Posted 13 August 2008
Posted to: Developmental Biology, Ecology, Evolutionary Biology
Weight Stigma and Educators’ Perceptions of Children’s Psychological Symptoms
Objective: To investigate whether weight stigma influences educators’ judgments about psychological symptoms in children.Design: Experimental study manipulating the weight status of children with s…
Received 29 July 2008 20:38 UTC; Posted 01 August 2008
Posted to: Developmental Biology
Introduction of Transmembrane Inner Ear (tmie) Gene Can Recover the Hearing Impairment and Abnormal Behavior in the Circling Mouse
The spontaneous mutant circling mouse (cir/cir) shows a circling behavior and hearing loss. We produced transgenic mice overexpressing the causative gene, transmembrane inner ear (tmie), for the ph…
Received 22 July 2008 07:13 UTC; Posted 28 July 2008
Posted to: Developmental Biology, Genetics & Genomics, Neuroscience
Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity
In the previous studies, we showed that strong Fgf8 signaling activates the Ras-ERK pathway to induce cerebellum. Here, we show importance of negative regulation of this pathway. ‘Prolonged’ activa…
Received 18 July 2008 06:30 UTC; Posted 18 July 2008
Posted to: Developmental Biology, Molecular Cell Biology, Neuroscience
Biocommunication of Fungal Organisms
The development and growth of fungal organisms depend on successful communication processes (a) within the organism and between organisms, (b) with the same or related species and (c) with non-rela…
Received 13 May 2008 17:29 UTC; Posted 14 May 2008
Posted to: Developmental Biology, Genetics & Genomics, Microbiology
Trichoplax, the simplest known animal, contains an estrogen-related receptor: Implications for the evolution of vertebrate and invertebrate estrogen receptors
Although, as their names imply, vertebrate and invertebrate estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to eac…
Received 06 May 2008 21:45 UTC; Posted 06 May 2008
Posted to: Developmental Biology, Ecology, Evolutionary Biology
The Genetic Signature of Perineuronal Oligodendrocytes
Oligodendrocytes in the central nervous system can be categorized as precursors, myelin-forming, and non-myelinating perineuronal cells. The function of perineuronal oligodendrocytes is unknown; it…
Received 22 April 2008 00:05 UTC; Posted 22 April 2008
Posted to: Developmental Biology, Genetics & Genomics, Neuroscience, Bioinformatics
Motif analysis of amphioxus, lamprey and invertebrate estrogen receptors and amphioxus and human estrogen-related receptors: Towards a better understanding of estrogen receptor evolution
Background. The origins of steroid-dependent regulation of the vertebrate estrogen receptor (ER) are poorly understood. Genes with statistically significant sequence similarity to vertebrate ER…
Received 11 April 2008 21:28 UTC; Posted 14 April 2008
Posted to: Cancer, Developmental Biology, Ecology, Evolutionary Biology
