Developmental Biology
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The Sonic Hedgehog Pathway Stimulates Prostate Tumor Growth by Paracrine Signaling and Recaptures Embryonic Gene Expression in Tumor Myofibroblasts
The Hedgehog (Hh) pathway contributes to prostate cancer growth and progression. The presence of robust Shh expression in both normal prostate and localized cancer challenged us to explain the uniq…
Received 24 August 2009 17:35 UTC; Posted 26 August 2009
Posted to: Cancer, Developmental Biology
Adverse Effects of Trichothiodystrophy DNA Repair and Transcription Gene Abnormalities on Human Fetal Development
The effects of DNA repair and transcription genes in human prenatal life have never been studied. Trichothiodystrophy (TTD) is a rare (affected frequency of 10-6) recessive disorder caused by mut…
Received 08 August 2009 21:45 UTC; Posted 11 August 2009
Posted to: Developmental Biology, Genetics & Genomics
Modeling reaction-diffusion of molecules on surface and in volume spaces with the E-Cell System
The-Cell System is an advanced open-source simulation platform to model and analyze biochemical reaction networks. The present algorithm modules of the system assume that the reacting molecules are…
Received 31 July 2009 15:41 UTC; Posted 31 July 2009
Posted to: Developmental Biology, Microbiology, Bioinformatics
mRNA diffusion explains protein gradients in Drosophila early development
We propose a new model describing the production and the establishment of the stable gradient of the Bicoid protein along the antero-posterior axis of the embryo of Drosophila. In this model, we …
Received 06 July 2009 14:12 UTC; Posted 06 July 2009
Posted to: Developmental Biology, Bioinformatics
Transformation of metabolism with age and lifestyle in Antarctic seals: a case study of systems biology approach to cross-species microarray experiment
Background: The metabolic transformation that changes Weddell seal pups born on land into aquatic animals is not only interesting for the study of general biology, but it also provides a model …
Received 28 June 2009 22:57 UTC; Posted 29 June 2009
Posted to: Developmental Biology, Ecology, Bioinformatics
Independent elaboration of steroid hormone signaling pathways in Metazoans
Steroid hormones regulate many physiological processes in vertebrates, nematodes and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcripti…
Received 25 June 2009 20:55 UTC; Posted 26 June 2009
Posted to: Cancer, Developmental Biology, Bioinformatics, Earth & Environment, Evolutionary Biology
Animal emergence during Snowball Earths by thermosynthesis in submarine hydrothermal vents
Darwin already commented on the lateness in the fossil record of the emergence of the animals, calling it a valid argument against his theory of evolution1. This emergence of the animals (metazoa…
Received 18 June 2009 13:05 UTC; Posted 19 June 2009
Posted to: Developmental Biology, Evolutionary Biology
Aging as a consequence of misrepair—A novel theory of aging
It is now increasingly realized that the underlying mechanisms which govern aging is a complex interplay of genetic regulation and damage accumulation. Aging as a result of accumulation of ‘faults’…
Received 15 June 2009 13:25 UTC; Posted 17 June 2009
Posted to: Developmental Biology, Evolutionary Biology
3D model of amphioxus steroid receptor complexed with estradiol
The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chorda…
Received 03 June 2009 21:14 UTC; Posted 05 June 2009
Posted to: Cancer, Developmental Biology, Bioinformatics, Evolutionary Biology
Transduction Pathways Regulating The Trophic effects of Saccharomyces boulardii in Rat small intestinal mucosa
S . boulardii is a probiotic yeast widely prescribed in a lyophilized form that determines in human and rat small intestine several effects including endoluminal secretion of enzymes and of polya…
Received 11 April 2009 08:14 UTC; Posted 14 April 2009
Posted to: Developmental Biology, Microbiology
