Chemistry
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Glutathione (GSH) conjugates with dopamine (DA)-derived quinones to form reactive or non-reactive GSH-conjugates
In this study we demonstrate for the first time that GSH could rapidly conjugate with dopamine (DA)-derived DA-o-quinones without enzymatic catalysis to form short-lived intermediate GSH-conjugates…
Received 21 March 2009 11:03 UTC; Posted 23 March 2009
Posted to: Biotechnology, Chemistry, Neuroscience, Pharmacology
ADME/Tox WEB in silico predictions of longer chain perfluoroalkyl carboxylic acid pKa values are more accurate than other computational methods
Perfluoroalkyl carboxylates are contaminants whose environmental fate and toxicological effects are of broad interest within the academic, industrial, and governmental science and regulatory commun…
Received 09 March 2009 03:41 UTC; Posted 10 March 2009
Posted to: Chemistry, Pharmacology, Earth & Environment
Golden sections of inter-atomic distances as exact ionic radii of atoms
The Golden ratio which appears in the geometry of a variety of creations in Nature is found to arise right in the Bohr radius of the hydrogen atom due to the opposite charges of the electron and pr…
Received 05 March 2009 17:07 UTC; Posted 10 March 2009
Posted to: Chemistry
Extending the semi-empirical PM6 method for carbon oxyacid pKa prediction to sulfonic acids: Application towards congener-specific estimates for the environmentally and toxicologically relevant C1 through C8 perfluoroalkyl derivatives
A positive bias in the semi-empirical PM6 method for estimating pKa values of sulfonic acids was corrected by a correlation developed between non-adjusted PM6 pKa values and the corresponding exper…
Received 05 March 2009 00:53 UTC; Posted 06 March 2009
Posted to: Chemistry, Earth & Environment
Ultrasonicated synthesis of 1-(2-hydroxyaryl)-3-(pyrrolidin-1-yl)-prop-2-en-1-ones and their antimicrobial screening
Abstract: A facile synthesis of title compounds has been carried out under ultrasound irradiation. The main advantages of the present procedure are shorter reaction time and higher yield. Products …
Received 05 February 2009 18:32 UTC; Posted 09 February 2009
Posted to: Chemistry
Reputation, authority and incentives. Or: How to get rid of the Impact Factor
A short intro into the impact factor and its limitations and potential successors.
Received 18 January 2009 19:55 UTC; Posted 21 January 2009
Posted to: Chemistry, Molecular Cell Biology, Bioinformatics
A Reaction Route Approach to Flux Balance Analysis
Background: Flux balance and network-based pathway analyses are theoretical tools aimed to find optimal steady state flux distributions in a metabolic network subject to additional constraints on t…
Received 14 January 2009 22:44 UTC; Posted 15 January 2009
Posted to: Biotechnology, Chemistry, Bioinformatics
Structure-based design of novel pyrazoles as aurora kinase A inhibitors.
Inhibition of Aurora kinase, a member of serine/threonine kinase involved in the regulation of cell division is emerging as a new molecular targeted cancer treatment option. Three isoforms of Auror…
Received 10 January 2009 02:52 UTC; Posted 12 January 2009
Posted to: Biotechnology, Cancer, Chemistry
Polyethylenimine-Modified Multiwalled Carbon Nanotubes for Plasmid DNA Gene Delivery
An efficient molecular delivery technique based on the transporting high-molecular-weight PEI 600K-modified multiwalled carbon nanotubes (PEI 600K-MWCNTs) into cell membranes is reported. The PEI 6…
Received 05 January 2009 07:22 UTC; Posted 07 January 2009
Posted to: Biotechnology, Cancer, Chemistry
Optical and Electrical Properties of Multi-Walled Carbon Nanotubes Functionalized with Oxadiazole Chromophores
Multi-walled carbon nanotubes (MWCNTs) functionalized with oxadiazole chromophores, 2-(4-aminophenyl)-5-naphthyl-1,3,4-oxadiazole (APND) was prepared by an amide linkage. The resultant MWCNTs-APND …
Received 04 January 2009 00:52 UTC; Posted 07 January 2009
Posted to: Chemistry
