Cancer
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Homologous self-organising scale-invariant properties characterise long range species spread and cancer invasion
Occupancy of new habitats through dispersion is a central process in nature. In particular, long distance dispersal is involved in the spread of species and epidemics, although it has not been prev…
Received 19 October 2007 12:31 UTC; Posted 19 October 2007
Proapoptotic Bid Association with Mre11-Rad50-Nbs1 Complex is Indispensable for Checkpoint Activation after DNA Damage
The proapoptotic protein Bid is phosphorylated by ATM after double strand breaks (DSBs) induction and induces S-phase arrest by a mechanism that remains to be elucidated. Here we show that in mamma…
Received 03 October 2007 13:09 UTC; Posted 03 October 2007
Posted to: Cancer, Molecular Cell Biology
Diagnostic robustness of DNA microarrays in the classification of acute leukemia
Countless statistical methods have been described for the analysis of DNA microarrays, and each yields distinct results. This raises the question whether DNA microarrays are robust diagnostic tools…
Received 20 September 2007 15:34 UTC; Posted 26 September 2007
Posted to: Biotechnology, Cancer, Genetics & Genomics, Molecular Cell Biology, Pharmacology, Bioinformatics
Pregnancy Obstructs Involution Stage II of the Mammary Gland in Cows: General Biological Implications
BackgroundRepeated research findings over the last 4 decades show that involution of mammary glands in dairy cows did not regress to same extend as that noticed in other mammalian species.*...
Received 03 September 2007 11:42 UTC; Posted 03 September 2007
Posted to: Cancer, Developmental Biology, Immunology
Metastasis as a faulty recapitulation of ontogeny
RAF oncogenes are involved in a variety of phenotypic switch phenomena. If for example oncogenic RAF is expressed together with Myc in B lineage cells, a lineage switch to macrophages occurs at low…
Received 23 August 2007 09:49 UTC; Posted 23 August 2007
Posted to: Cancer, Developmental Biology, Genetics & Genomics
Opposite effects of two zinc(II) dithiocarbamates on NF-kB pathway
Inhibiting nuclear factor-kappaB (NF-kB) activation in anticancer and antiinflammatory therapy is of topical interest. Current research in molecular biology has dramatically advanced in the underst…
Received 15 August 2007 11:21 UTC; Posted 16 August 2007
Posted to: Cancer, Chemistry, Molecular Cell Biology, Pharmacology
Direct fluorophore conjugation to genomic DNA for microarray-based epigenomic profiling
A methodology for microarray based epigenomic profiling is presented. The method relies on platinum-based fluorescence labeling reagents for direct (non-enzymatic) labeling of DNA and RNA. This is …
Received 12 July 2007 16:09 UTC; Posted 12 July 2007
Posted to: Biotechnology, Cancer, Chemistry, Molecular Cell Biology
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies.
Canonical Wnt signaling is an osteo-inductive signal that promotes bone repair through acceleration of osteogenic differentiation by progenitors. Dkk-1 is a secreted inhibitor of canonical Wnt sign…
Received 20 June 2007 14:47 UTC; Posted 21 June 2007
Posted to: Biotechnology, Cancer
The CombiUgi Project and Closing the Open Science Loop
This presentation combines 2 blog posts explaining the CombiUgi project and the predicted anti-tumor activity of a virtual library of 68,000 compounds.
Received 19 June 2007 16:23 UTC; Posted 20 June 2007
Posted to: Cancer, Chemistry, Bioinformatics
PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.
The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive. Here we show that PIM1 contributes to the…
Received 19 June 2007 14:34 UTC; Posted 20 June 2007
Posted to: Cancer, Molecular Cell Biology
