Cancer
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Markedly enhanced intratumoral spread and antitumor effect of oncolytic adenovirus expressing decorin
With the aim of improving viral distribution and tumor penetration, we have engineered decorin expressing replication-incompetent (dl-LacZ-DCNG) and -competent (Ad-ΔE1B-DCNG) adenoviruses. In…
Received 03 January 2008 09:06 UTC; Posted 03 January 2008
Posted to: Cancer
Are plants with anti-cancer activity resistant to crown gall? : A test of hypothesis
The Crown gall tumour assay (CGTA) is one of several bench top bioassays recommended for the rapid screening of plants with anti-cancer activity. The rationale for the use of the bioassay is that t…
Received 22 December 2007 10:30 UTC; Posted 28 December 2007
Posted to: Cancer, Pharmacology, Plant Biology
Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues
Iridium complex, a promising organic light-emitting diode for next generation television displays, emits phosphorescence. Phosphorescence is quenched by oxygen. We used this oxygen-quenching featur…
Received 19 December 2007 23:59 UTC; Posted 20 December 2007
Posted to: Biotechnology, Cancer, Chemistry
A new potential radiosensitizer: ammonium persulfate modified WCNTs
Radiotherapy plays a very important role in cancer treatment. Radiosensitizers have been widely used to enhance the radiosensitivity of cancer cells at given radiations. Here we fabricate multi-wal…
Received 13 December 2007 10:19 UTC; Posted 04 January 2008
Posted to: Biotechnology, Cancer, Chemistry
TMEPAI, a transmembrane TGF-β-inducible protein, sequesters Smad proteins in TGF-β signaling
Transforming growth factor-β (TGF-β) is a multifunctional cytokine of key importance for controlling embryogenesis and tissue homeostasis. How TGF-β signals are attenuated and termin…
Received 07 December 2007 04:05 UTC; Posted 07 December 2007
Posted to: Cancer, Molecular Cell Biology
ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes
ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets. However, most ChIP-on-chip analysis methods us…
Received 26 November 2007 20:49 UTC; Posted 28 November 2007
Posted to: Cancer, Genetics & Genomics, Bioinformatics
Method of Detecting and Targeting Mutations in Cancer
While there are many differences between tumor and non-tumor cells, the basic underlying distinction is in the DNA. Tumor cells harbor mutations, at least some of which are not present in non-tumo…
Received 13 November 2007 22:02 UTC; Posted 13 November 2007
Posted to: Cancer
The NCI-Nature Pathway Interaction Database: A cell signaling resource.
The Pathway Interaction Database (PID, http://pid.nci.nih.gov) is a freely availablecollection of curated and peer-reviewed signaling pathways composed of humanbiomolecular interactions and c…
Received 12 November 2007 16:17 UTC; Posted 12 November 2007
Posted to: Cancer, Molecular Cell Biology, Bioinformatics
Is the infection/latency/reactivation cycle of viruses an oncogenic engine?
Human oncogenic viruses are defined as necessary but not sufficient to initiate cancer. Experimental evidence suggests that the oncogenic potential of a virus is effective only in cells that have a…
Received 31 October 2007 16:53 UTC; Posted 31 October 2007
Posted to: Cancer, Microbiology, Molecular Cell Biology
Artificial Antigen Presenting Cells With Preclustered anti-CD28/-CD3/-LFA-1 Monoclonal Antibodies Are Highly Effective To Induce The Ex-Vivo Expansion Of Functional Human Antitumor T Cells
Effective adoptive T cell therapy requires the ex vivo generation of functional T lymphocytes with a long lifespan in vivo. We evaluated in vitro T cell expansion by artificial antigen presen…
Received 24 October 2007 10:43 UTC; Posted 24 October 2007
Posted to: Biotechnology, Cancer, Immunology
