Cancer
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A novel regulator of the p53-mediated mitochondrial apoptotic pathway
The p53 tumor suppressor protein induces apoptosis in response to genotoxic and environmental stress. Recent studies have revealed the existence of a transcription-independent mitochondrial p53 apo…
Received 15 May 2008 07:13 UTC; Posted 16 May 2008
Posted to: Cancer, Molecular Cell Biology
Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis
AML1/RUNX1 is a critical transcription factor in hematopoietic cell differentiation and proliferation. From the AML1 gene, at least three isoforms, AML1a, AML1b and AML1c, are produced thro…
Received 14 April 2008 01:44 UTC; Posted 14 April 2008
Posted to: Cancer, Molecular Cell Biology
Motif analysis of amphioxus, lamprey and invertebrate estrogen receptors and amphioxus and human estrogen-related receptors: Towards a better understanding of estrogen receptor evolution
Background. The origins of steroid-dependent regulation of the vertebrate estrogen receptor (ER) are poorly understood. Genes with statistically significant sequence similarity to vertebrate ER…
Received 11 April 2008 21:28 UTC; Posted 14 April 2008
Posted to: Cancer, Developmental Biology, Ecology, Evolutionary Biology
Connecting Seed Lists of Mammalian Proteins Using Steiner Trees
Multivariate experiments and genomics studies applied to mammalian cells often produce lists of genes or proteins altered under treatment/disease vs. control/normal conditions. Such lists can be id…
Received 05 April 2008 20:54 UTC; Posted 07 April 2008
Posted to: Biotechnology, Cancer, Molecular Cell Biology, Bioinformatics
Transforming growth factor-beta 1 (tgf-β1) induces angiogenesis through vascular endothelial growth factor (vegf)-mediated apoptosis
VEGF and TGF-β1 induce angiogenesis but have opposing effects on endothelial cells. VEGF protects endothelial cells from apoptosis; TGF-β1 induces apoptosis. We have previously shown that…
Received 02 April 2008 16:49 UTC; Posted 03 April 2008
Posted to: Cancer
Requirement of RIZ1 for cancer prevention by methyl-balanced diet
The typical Western diet is not balanced in methyl nutrients that regulate the level of the methyl donor S-adenosylmethionine (SAM) and its derivative metabolite S-adenosylhomocysteine (SAH), which…
Received 27 March 2008 17:58 UTC; Posted 28 March 2008
Posted to: Cancer, Genetics & Genomics
Beneficial role of allicin from garlic in cervical cancer
Introduction: Cervical cancer remains a global health concern for females. Thus, in order to control cervical cancer, attempts are being made by researchers globally to somehow induce programmed ce…
Received 01 February 2008 12:21 UTC; Posted 01 February 2008
Posted to: Cancer, Molecular Cell Biology
Tumor-associated EGFR over-expression specifically activates Stat3 and Smad7 resulting in desensitization of TGF-β signaling
Transforming Growth Factor-β (TGF-β) and Epidermal Growth Factor (EGF) signaling pathways are both independently implicated as key regulators in tumor formation and progression. Here, we …
Received 23 January 2008 01:47 UTC; Posted 23 January 2008
Posted to: Cancer, Molecular Cell Biology
The potential of Manitoba chokecherry as a source of high natural antioxidants
Consumption of fruits and vegetables is shown to be beneficial for protecting health and preventing some chronic diseases such as cancer, cardiovascular disease, and stroke. The positive health eff…
Received 22 January 2008 00:23 UTC; Posted 22 January 2008
Posted to: Cancer, Chemistry, Plant Biology
Chemistry Crowdsourcing and Open Notebook Science
This is a pre-proposal written for the NSF program CDI (Cyber-Enabled Discovery and Innovation) in Jan 2008.The current system of dissemination of scientific data and knowledge is far less eff…
Received 09 January 2008 19:29 UTC; Posted 10 January 2008
Posted to: Cancer, Chemistry, Bioinformatics
