Cancer
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PID: The Pathway Interaction Database
The Pathway Interaction Database (PID, http://pid.nci.nih.gov) is a freely available collection of curated and peer-reviewed pathways composed of human molecular signaling …
Received 29 August 2008 01:06 UTC; Posted 29 August 2008
Posted to: Cancer, Molecular Cell Biology, Bioinformatics
A network-based signaling mechanism of cancer development and progression
We conducted a comprehensive analysis of a manually curated human signaling network containing 1634 nodes and 5089 signaling regulatory relations by integrating cancer-associated genetically and ep…
Received 27 August 2008 19:33 UTC; Posted 27 August 2008
Posted to: Cancer, Genetics & Genomics, Bioinformatics
Multifunctional Nanoparticles for Imaging Guided Interventions
We describe multifunctional magnetic nanoparticles (MNPs) encapsulated in thermosensitive, drug-bearing shells and delivered to the tumor site by genetically modified and non-pathogenic strains of …
Received 14 August 2008 12:03 UTC; Posted 21 August 2008
Posted to: Biotechnology, Cancer
Serum profiling and biomarker discovery of rat mammary tumors using mass-coded abundance tags (MCAT)
Advances in Mass-spectrometry techniques allow for the rapid processing and evaluation of complex biological mixtures such as blood/serum. These samples represent a protein rich environment as well…
Received 02 July 2008 20:52 UTC; Posted 03 July 2008
Posted to: Cancer
Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms.
PPP1R13L was initially identified as a protein that binds to the NF-κB subunit p65/RelA and inhibits its transcriptional activity. It also binds p53 and inhibits its action. One set of experi…
Received 24 June 2008 16:03 UTC; Posted 24 June 2008
Posted to: Cancer
The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma
We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortez…
Received 23 June 2008 15:46 UTC; Posted 12 July 2008
Posted to: Cancer, Pharmacology
14-3-3ζ is Amplified, Overexpressed and Possesses Oncogenic Activities in Head and Neck Squamous Cell Carcinoma
Gene amplification, a common mechanism for oncogene activation in cancers, has been used in the discovery of novel oncogenes. DNA amplification is frequently observed in head and neck squamous cell…
Received 06 June 2008 20:46 UTC; Posted 09 June 2008
Posted to: Cancer
11-amino-5-N-methyl-7-fluorine- quindoline derivatives: The Potential Anti-angiogenic Agents Targeting G-quadruplex Structure in Vascular Endothelial Cell Growth Factor
Vascular endothelial growth factor (VEGF), a pluripotent cytokine and angiogenic growth factor, plays crucial roles in embryonic development and tumour progression, and is over-expressed in many ty…
Received 04 June 2008 20:26 UTC; Posted 10 June 2008
Posted to: Cancer
Potential role of 2,2’-biphenylquinones in the carcinogenic/anti-cancer activity of dioxins
Modes of carcinogenicity for the well-known environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been investigated over the past several decades. However, the mechanisms underl…
Received 30 May 2008 03:57 UTC; Posted 31 May 2008
HBsAg-vectored DNA vaccines elicit concomitant protective responses to multiple CTL epitopes relevant in human disease.
Vaccines capable of controlling neoplastic and infectious diseases which depend on the cellular immune response for their resolution, have proven difficult to develop. We, and others, have previous…
Received 26 May 2008 05:03 UTC; Posted 27 May 2008
Posted to: Biotechnology, Cancer, Immunology
