Cancer
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Optimal control circuitry design for the digital p53 dynamics in cancer cell and apoptosis
Experimental work and theoretical models deduce a “digital” response of the p53 transcription factor when genomic integrity is damaged. The mutual influence of p53 and its antagonist, the Mdm2 onco…
Received 13 February 2009 00:02 UTC; Posted 17 February 2009
Posted to: Biotechnology, Cancer, Developmental Biology
Myosin II isoforms with separate but linked functions determine the fate of lamellipodia extension during cell spreading
Non-muscle myosin II role has been implicated in the extension of lamellipodia, a critical step in the initiation of directed cell migration, invasion and other cellular processes, but the mechanis…
Received 11 February 2009 23:38 UTC; Posted 18 February 2009
Posted to: Cancer, Microbiology, Molecular Cell Biology
Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells. H…
Received 30 January 2009 04:54 UTC; Posted 30 January 2009
Posted to: Cancer, Genetics & Genomics
Structure-based design of novel pyrazoles as aurora kinase A inhibitors.
Inhibition of Aurora kinase, a member of serine/threonine kinase involved in the regulation of cell division is emerging as a new molecular targeted cancer treatment option. Three isoforms of Auror…
Received 10 January 2009 02:52 UTC; Posted 12 January 2009
Posted to: Biotechnology, Cancer, Chemistry
Frizzled Proteins are bona fide G Protein-Coupled Receptors
Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controllingmultiple steps in organism development and highly conserved in evolution.Misactivation of the Wnt/Frizzled si…
Received 08 January 2009 16:38 UTC; Posted 09 January 2009
Posted to: Cancer, Developmental Biology, Molecular Cell Biology, Pharmacology
Polyethylenimine-Modified Multiwalled Carbon Nanotubes for Plasmid DNA Gene Delivery
An efficient molecular delivery technique based on the transporting high-molecular-weight PEI 600K-modified multiwalled carbon nanotubes (PEI 600K-MWCNTs) into cell membranes is reported. The PEI 6…
Received 05 January 2009 07:22 UTC; Posted 07 January 2009
Posted to: Biotechnology, Cancer, Chemistry
Limiting effect of diazepam on Lewis lung carcinoma metastasis in anxious male mice
Aim: It has been shown previously that chronic social defeat stress produces development of strong anxiety and increases intensity of experimental metastasis in the losers in comparison with the …
Received 03 January 2009 06:13 UTC; Posted 05 January 2009
Posted to: Cancer, Neuroscience, Pharmacology
The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”. Hypothesis: The nitroimidazole induced metabolic energy loss a…
Received 30 December 2008 21:07 UTC; Posted 30 December 2008
Posted to: Biotechnology, Cancer, Pharmacology
Computational methods in cancer gene networking
In the past few years, many high-throughput techniques have been developed and applied to biological studies. These techniques such as “next generation” genome sequencing, chip-on-chip, microarray …
Received 30 December 2008 19:47 UTC; Posted 06 January 2009
Posted to: Cancer, Genetics & Genomics, Bioinformatics
Down-regulation of Survivin enhances sensitivity to BPR0L075 in human cancer cells via caspase-independent mechanisms
Background: BPR0L075 [6-methoxy-3-(3’,4’,5’-trimethoxy-benzoyl)-1H-indole] is a novel anti-cancer compound. It inhibits tubulin polymerization and induces mitochondrial-dependent apoptosis in vario…
Received 29 December 2008 09:16 UTC; Posted 29 December 2008
Posted to: Cancer
