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The History, Development and Impact of Computed Imaging in Neurological Diagnosis and Neurosurgery: CT, MRI, and DTI
A steady series of advances in physics, mathematics, computers and clinical imaging science have progressively transformed diagnosis and treatment of neurological and neurosurgical disorders in the…
Received 30 June 2009 19:55 GMT; Posted 01 July 2009
Posted to: Biotechnology, Cancer, Neuroscience
Independent elaboration of steroid hormone signaling pathways in Metazoans
Steroid hormones regulate many physiological processes in vertebrates, nematodes and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcripti…
Received 25 June 2009 20:26 GMT; Posted 26 June 2009
Posted to: Cancer, Developmental Biology, Bioinformatics, Earth & Environment, Evolutionary Biology
Polymorphisms of CYP1A1 I462V and GSTM1 genotypes and lung cancer susceptibility in Mongolian
Aim: To study the genotype of cytochrome P450 1A1(CYP1A1) I462V and glutathions S-transferase M1( GSTM1) and the relationship of the genetic polymorphism of them with the susceptibility of lung can…
Received 12 June 2009 00:19 GMT; Posted 18 June 2009
Posted to: Cancer, Pharmacology
3D model of amphioxus steroid receptor complexed with estradiol
The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chorda…
Received 03 June 2009 21:05 GMT; Posted 05 June 2009
Posted to: Cancer, Developmental Biology, Bioinformatics, Evolutionary Biology
Enhanced anti-tumor effects of combined MDR1 RNA interference and human sodium/iodide symporter (NIS) radioiodine gene therapy using an adenoviral system in a colon cancer model
Using an adenoviral system as a delivery mediator of therapeutic gene, we investigated the therapeutic effects of the use of combined MDR1 shRNA and human NIS (hNIS) radioiodine gene therapy in…
Received 02 June 2009 13:10 GMT; Posted 02 June 2009
Posted to: Cancer
Rethinking Leucine Zipper – a ubiquitous signal transduction motif
In this essay we attempt to reconsider the concept of the “Leucine Zipper” (LZ) protein oligomerization motif. Reasoning on the wealth of existing data, we suggest that despite of the structural si…
Received 21 May 2009 23:07 GMT; Posted 22 May 2009
Posted to: Cancer, Immunology, Molecular Cell Biology, Bioinformatics
Carrier cell-mediated cell lysis of squamous cell carcinoma by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus
The squamous cell carcinoma antigen (SCCA) serves as a serological marker for squamous cell carcinomas. Molecular cloning of the SCCA genomic region has revealed the presence of two tandemly arraye…
Received 02 May 2009 09:11 GMT; Posted 08 May 2009
Posted to: Cancer
Enhanced anti-cancer activity of microglia by AAV2-mediated IL-12 in the therapy of glioblastoma multiforme
Microglia has been found to diversify its function by cancerous cells or in a cancerous environment, thereby contributing to cancer growth and metastasis. Its immuno-activity, however, can be modul…
Received 20 April 2009 10:35 GMT; Posted 24 April 2009
Posted to: Cancer
Parallel routes of human carcinoma development: Implications of the age-specific incidence data
The multi-stage hypothesis suggests that cancers develop through a single defined series of genetic alterations. This hypothesis was first suggested over 50 years ago based upon age-specific incide…
Received 17 April 2009 18:11 GMT; Posted 17 April 2009
Posted to: Cancer, Genetics & Genomics
Talin1 Promotes Prostate Cancer Invasion and Metastasis via AKT Signaling and Anoikis Resistance
Talin1 is an integrin regulatory protein that mediates integrin interactions with the extracellular matrix (ECM). This study investigated the significance of talin1 in prostate cancer progression t…
Received 10 April 2009 19:14 GMT; Posted 14 April 2009
Posted to: Cancer
