Biotechnology
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Local and global modes of drug action in biochemical networks
It becomes increasingly accepted that a shift is needed from the traditional target-based approach of drug development to an integrated perspective of drug action in biochemical systems. We here pr…
Received 13 November 2008 15:22 UTC; Posted 14 November 2008
Posted to: Biotechnology
Substrate entering and product leaving trajectories predict an engulfing dynamic for the major conformational change of the β-lactam acylase
It is still a major challenge to acquire insight into the conformational changes between the ground state and the transition state of an enzyme, although conformational fluctuation within interconv…
Received 13 November 2008 06:24 UTC; Posted 15 November 2008
Posted to: Biotechnology
Temperature factor analysis of outer membrane β-stranded porin crystal structures suggests the pore is not uniformly rigid
Outer membrane beta-stranded porins form a diverse and complex set of proteins which allow passage of molecules across the membrane interface have been analyzed here from a biophysical and structur…
Received 10 November 2008 13:54 UTC; Posted 12 November 2008
Posted to: Biotechnology
Fracture Toughness of Human Solid Cancers
Human solid cancers typically are harder and firmer than surrounding normal tissue upon clinical palpation. This characteristic has been linked to the presence of abundant collagen in the tumor str…
Received 02 November 2008 22:42 UTC; Posted 10 November 2008
Posted to: Biotechnology, Cancer
Detection of genetic diversity among Indian strains of Xanthomonas campestris pv. mangiferaeindicae using PCR-RAPD
The randomly amplified polymorphic DNA (RAPD) technique was used to investigate the genetic diversity in 6 strains of Xanthomonas campestris pv. mangiferaeindicae (Xcmi), the causal pathogen …
Received 16 October 2008 15:53 UTC; Posted 16 October 2008
Posted to: Biotechnology, Microbiology
Facile Synthesis and Versatilities of Polyanthraquinoylamine Nanofibril Bundles with Self Stability and High Carbon Yield
A facile synthesis for nanosized conducting polymers with inherent self-stability and multi-functionalities is a main challenge. Here we simply synthesize intrinsically self-stabilized nanofibril b…
Received 14 October 2008 11:11 UTC; Posted 15 October 2008
Posted to: Biotechnology, Chemistry
pFAR plasmids: New Eukaryotic Expression Vectors for Gene Therapy, devoid of Antibiotic Resistance Markers
Efficient production of eukaryotic expression vectors requires the selection of plasmid-containing bacteria. To avoid the risk of dissemination of antibiotic resistance markers, we developed a new …
Received 13 October 2008 09:15 UTC; Posted 17 October 2008
Posted to: Biotechnology, Genetics & Genomics
Regulating Nanomedicine: A European perspective
The potential impact of nanomedicine is foreseen to radically change health care; however it also challenges existing perceptions, dynamics and standards relating to ethics, safety and governance. ...
Received 10 October 2008 08:46 UTC; Posted 14 October 2008
Posted to: Biotechnology
FDserver: A web service for protein folding research
Summary: To facilitate the study of protein folding, we have developed a web service for protein folding rate and folding type prediction as well as for the calculation of a variety of topologica…
Received 01 October 2008 22:11 UTC; Posted 02 October 2008
Posted to: Biotechnology, Bioinformatics
Overnight weight loss: relationship with sleep structure and heart rate variability
Background: Weight loss can be caused by a loss of body mass due to metabolism and by water loss as unsensible water loss, sweating, or excretion in feces and urine. Although weight loss during sle…
Received 30 September 2008 18:50 UTC; Posted 30 September 2008
Posted to: Biotechnology, Neuroscience
