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Optimal control circuitry design for the digital p53 dynamics in cancer cell and apoptosis
Experimental work and theoretical models deduce a “digital” response of the p53 transcription factor when genomic integrity is damaged. The mutual influence of p53 and its antagonist, the Mdm2 onco…
Received 13 February 2009 00:02 UTC; Posted 17 February 2009
Posted to: Biotechnology, Cancer, Developmental Biology
Intestinal Electric Stimulation Accelerates Whole Gut Transit and Promotes Fat Excrement in Conscious Rats
Introduction: Intestinal electric stimulation (IES) is proposed as a potential tool for the treatment of morbid obesity. Our previous study showed that IES with one pair of electrodes accelerat…
Received 05 February 2009 04:27 UTC; Posted 05 February 2009
Posted to: Biotechnology
Emergence and Fixing of Antiviral Resistance in Influenza A Via Recombination and Hitch Hiking
The dramatic rise of oseltamivir resistance in the H1N1 serotype in the 2007/2008 season and the fixing of H274Y in the 2008/2009 season has raised concerns regarding individuals at risk for season…
Received 29 January 2009 21:07 UTC; Posted 10 February 2009
Posted to: Biotechnology, Genetics & Genomics, Immunology
Single cell fertilizer (SCF): Evidence to prove that bio-molecules are potent nutrient for plant growth
Fertilizers of various kinds are used for the cultivation of crop plants for hyper production of plant based food materials. The study used bio-molecules made in a bacterial cell. The experimental …
Received 25 January 2009 05:43 UTC; Posted 06 February 2009
Posted to: Biotechnology
Proof of principle for shotgun DNA mapping by unzipping
Ability to map polymerases and nucleosomes on chromatin is important for understanding the impact of chromatin remodeling on key cellular processes. Current methods (such as ChIP and ChIP-chip) ha…
Received 20 January 2009 23:52 UTC; Posted 21 January 2009
Posted to: Biotechnology, Genetics & Genomics
Inhibition of pteridine reductase 1 (PTR1) expression in Leishmania promastigotes using a full-length antisense construct
Leishmania exhibit many unusual features, one of which is the pteridine metabolic pathway essential for the growth for these parasites. Leishmania have evolved a complex and versatile pteridine sal…
Received 20 January 2009 20:17 UTC; Posted 22 January 2009
Posted to: Biotechnology
Structural analysis of outer membrane beta-stranded porins using B-factor
Computational and statistical analysis has formed a large component of the biophysical efforts put forth to understand protein structure and function, due to the diversity and complexity of their s…
Received 20 January 2009 00:11 UTC; Posted 21 January 2009
Posted to: Biotechnology
A Reaction Route Approach to Flux Balance Analysis
Background: Flux balance and network-based pathway analyses are theoretical tools aimed to find optimal steady state flux distributions in a metabolic network subject to additional constraints on t…
Received 14 January 2009 22:44 UTC; Posted 15 January 2009
Posted to: Biotechnology, Chemistry, Bioinformatics
Narrow genetic and apparent phenetic diversity in Jatropha curcas: initial success with generating low phorbol ester interspecific hybrids
Due to the increasing popularity of Jatropha curcas as a feedstock for biodiesel, generating non-toxic and high yielding varieties of the plant requires genotypic characterization towards identifyi…
Received 13 January 2009 09:17 UTC; Posted 16 January 2009
Posted to: Biotechnology, Ecology, Genetics & Genomics, Earth & Environment, Plant Biology
Structure-based design of novel pyrazoles as aurora kinase A inhibitors.
Inhibition of Aurora kinase, a member of serine/threonine kinase involved in the regulation of cell division is emerging as a new molecular targeted cancer treatment option. Three isoforms of Auror…
Received 10 January 2009 02:52 UTC; Posted 12 January 2009
Posted to: Biotechnology, Cancer, Chemistry
