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High-Value Phytochemicals from Grape Cane Waste: Potential Value-Added Viticultural Sources of Trans-Resveratrol and Trans-e-Viniferin with Medicinal and Anti-Phytopathogenic Applications
Grape canes as agricultural waste from commercial viticultural activities represent a potentially important source of the well-known medicinal and anti-phytopathogenic stilbene compounds trans-resv…
Received 07 August 2007 01:49 UTC; Posted 07 August 2007
Posted to: Biotechnology, Chemistry, Pharmacology, Earth & Environment
Trichoderma reesei derived cellulase activity in three N,N-dimethylethanolammonium akylcarboxylate ionic liquids
The activity and denaturation extent of cellulase from Trichoderma reesei (E.C. # 3.2.1.4) was investigated in three representative N,N-dimethylethanolammonium akylcarboxylate ionic liquids. Signif…
Received 06 August 2007 23:27 UTC; Posted 07 August 2007
Posted to: Biotechnology, Chemistry
Direct fluorophore conjugation to genomic DNA for microarray-based epigenomic profiling
A methodology for microarray based epigenomic profiling is presented. The method relies on platinum-based fluorescence labeling reagents for direct (non-enzymatic) labeling of DNA and RNA. This is …
Received 12 July 2007 16:09 UTC; Posted 12 July 2007
Posted to: Biotechnology, Cancer, Chemistry, Molecular Cell Biology
Quantification of Cell Movement Reveals Distinct Edge Motility Types During Cell Spreading
Actin-based motility is central to cellular processes such as migration, bacterial engulfment, and cancer metastasis, and requires precise spatial and temporal regulation of the cytoskeleton. We st…
Received 08 July 2007 07:36 UTC; Posted 09 July 2007
Posted to: Biotechnology, Molecular Cell Biology
ProbCD: enrichment analysis accounting for categorization uncertainty
As in many other areas of science, systems biology makes extensive use of statistical association and significance estimates in contingency tables, a type of categorical data analysis known in this…
Received 06 July 2007 04:45 UTC; Posted 06 July 2007
Posted to: Biotechnology, Genetics & Genomics, Bioinformatics
Exploiting Nonlinear Recurrence and Fractal Scaling Properties for Voice Disorder Detection
Background: Voice disorders affect patients profoundly, and acoustic tools can potentially measure voice function objectively. Disordered sustained vowels exhibit wide-ranging phenomena, from nearl…
Received 02 July 2007 21:52 UTC; Posted 09 July 2007
Posted to: Biotechnology
The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies
Reproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the appar…
Received 02 July 2007 15:49 UTC; Posted 03 July 2007
Posted to: Biotechnology, Bioinformatics
Simcluster: clustering enumeration gene expression data on the simplex space
Transcript enumeration methods such as SAGE, MPSS, and sequencing-by-synthesis EST “digital northern”, are important high-throughput techniques for digital gene expression measurement. As other cou…
Received 23 June 2007 18:56 UTC; Posted 25 June 2007
Posted to: Biotechnology, Bioinformatics
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies.
Canonical Wnt signaling is an osteo-inductive signal that promotes bone repair through acceleration of osteogenic differentiation by progenitors. Dkk-1 is a secreted inhibitor of canonical Wnt sign…
Received 20 June 2007 14:47 UTC; Posted 21 June 2007
Posted to: Biotechnology, Cancer
Molecular Static and Dynamic Analyses reveal Flaw in Murine Model used by US FDA to Detect Drug Carcinogenicity
The US FDA currently accepts carcinogenicity studies of pharmaceutical drugs based on murine models. In addition to 6 month studies with p53(+/-) and ras.H2 transgenic mice, lifetime studies (typic…
Received 15 June 2007 18:05 UTC; Posted 15 June 2007
Posted to: Biotechnology, Cancer, Immunology, Pharmacology, Bioinformatics
