Bioinformatics
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Rethinking Leucine Zipper – a ubiquitous signal transduction motif
In this essay we attempt to reconsider the concept of the “Leucine Zipper” (LZ) protein oligomerization motif. Reasoning on the wealth of existing data, we suggest that despite of the structural si…
Received 22 May 2009 07:26 UTC; Posted 22 May 2009
Posted to: Cancer, Immunology, Molecular Cell Biology, Bioinformatics
Experimental demonstration of associative memory with memristive neural networks
When someone mentions the name of a known person we immediately recall her face and possibly many other traits. This is because we possess the so-called associative memory – the ability to correlat…
Received 18 May 2009 16:52 UTC; Posted 19 May 2009
Posted to: Neuroscience, Bioinformatics
Molecular evidence for the hadrosaur B. canadensis as an outgroup to a clade containing the dinosaur T. rex and birds
Molecular analysis of collagen sequences from an 80 million year old hadrosaur B. canadensis and a 68 million year old dinosaur T. rex suggest strongly that B. canadensis is an outgroup to a …
Received 15 May 2009 19:03 UTC; Posted 27 May 2009
Posted to: Bioinformatics, Evolutionary Biology
Biocuration Workflow Catalogue
As the first phase of a knowledge engineering study of biocuration workflows, we performed a preliminary task-modeling exercise on seven separate bioinformatics systems. This involved constructing …
Received 13 May 2009 18:00 UTC; Posted 13 May 2009
Posted to: Bioinformatics
Developing ontologies in decentralised settings
This paper addresses two research questions: “How should a well-engineered methodology facilitate the development of ontologies within communities of practice?” and “What methodology should be used…
Received 08 May 2009 07:51 UTC; Posted 08 May 2009
Posted to: Bioinformatics
An evolutionary approach to Function
The distinction between function and role is a vexed and difficult one. While the distinction appears to be useful, in practice it is hard to apply; this can be even worse when applying this distin…
Received 07 May 2009 11:34 UTC; Posted 11 May 2009
Posted to: Bioinformatics
Design of selective peptide antibiotics by using the sequence moment concept
WithdrawnIncomplete data
Received 02 May 2009 08:02 UTC; Posted 04 May 2009
Posted to: Biotechnology, Pharmacology, Bioinformatics
Reflect: Augmented Browsing for the Life Scientist
Anyone who regularly reads life science literature often comes across names of genes, proteins, or small molecules that they would like to know more about. To make this process easier, we have deve…
Received 02 May 2009 01:44 UTC; Posted 04 May 2009
Posted to: Biotechnology, Chemistry, Genetics & Genomics, Molecular Cell Biology, Bioinformatics
In silico Protein Structural Modeling and Active binding site Evaluation of Streptococcus pneumoniae
Structure function relation of glucose kinese in Streptococcus pneumoniae. However, a solved structure for Streptococcus pneumoniae glucose kinese is not available at the protein data bank. Gluco…
Received 30 April 2009 11:55 UTC; Posted 06 May 2009
Posted to: Molecular Cell Biology, Bioinformatics
Human ovarian reserve from conception to the menopause
Current understanding is that the human ovary contains a fixed number of several million non-growing follicles (NGF), established by five months of gestational age, that declines with increasing ag…
Received 27 April 2009 00:25 UTC; Posted 27 April 2009
Posted to: Bioinformatics
