Bioinformatics
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Modeling reaction-diffusion of molecules on surface and in volume spaces with the E-Cell System
The-Cell System is an advanced open-source simulation platform to model and analyze biochemical reaction networks. The present algorithm modules of the system assume that the reacting molecules are…
Received 31 July 2009 15:41 UTC; Posted 31 July 2009
Posted to: Developmental Biology, Microbiology, Bioinformatics
Searching for better flu surveillance? A brief communication arising from Ginsberg et al. Nature 457, 1012-1014 (2009)
Through retrospectively analyzing billions of internet search queries, Ginsberg et al. identified a collection of specific searches that track the course of influenza-like illness (ILI) reported by…
Received 28 July 2009 19:16 UTC; Posted 05 August 2009
Posted to: Microbiology, Bioinformatics
Gender differences in a Drosophila transcriptomic model of chronic pentylenetetrazole induced behavioral deficit
A male Drosophila model of locomotor deficit induced by chronic pentylenetetrazole (PTZ), a proconvulsant used to model epileptogenesis in rodents, has recently been described. Antiepileptic drugs …
Received 25 July 2009 08:04 UTC; Posted 27 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
A Drosophila systems model of withdrawal from chronic pentylenetetrazole relevant in post-epileptogenesis
Rodent kindling induced by pentylenetetrazole (PTZ) is an established model of epileptogenesis and antiepileptic drug (AED) testing. Recently, a Drosophila systems model has been described in which…
Received 21 July 2009 16:19 UTC; Posted 21 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
A simple clustering of the BioModels database using semanticSBML
The BioModels database contains biochemical network models in SBML format, in which the biochemical meaning of elements is specified by MIRIAM-compliant RDF annotations. We used these annotations t…
Received 20 July 2009 15:09 UTC; Posted 20 July 2009
Posted to: Bioinformatics
In silico analysis for the presence of HARDY an Arabidopsis drought tolerance DNA binding transcription factor product in chromosome 6 of Sorghum bicolor genome
Expression of the Arabidopsis HARDY (hrd) DNA binding transcription factor (555 bp present on chromosome 2) has been shown to increase WUE in rice by Karaba et al 2007 (PNAS, 104:15270–15275). We c…
Received 18 July 2009 04:04 UTC; Posted 20 July 2009
Posted to: Bioinformatics
A novel Drosophila transcriptomic and behavioral model detects potassium chloride with therapeutic potential
In a newly described Drosophila model, two of the five antiepileptic drugs (AEDs) tested, sodium valproate (NaVP) and levetiracetam (LEV), not ethosuximide (ETH), gabapentin (GBP) and vigabatrin …
Received 14 July 2009 15:23 UTC; Posted 17 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
Online Training of New Curators
The basic information in Reactome is provided by bench biologists who are experts on a particular pathway, the Reactome Team is always working hard to drive engagement. This engagement between expe…
Received 10 July 2009 19:14 UTC; Posted 13 July 2009
Posted to: Bioinformatics
A novel Drosophila post-genomic CNS drug discovery model detects tetraethylammonium chloride with therapeutic potential
A Drosophila behavioral and transcriptomic model of locomotor plasticity induced by chronic pentylenetetrazole (PTZ) has recently been developed. In this model, two of the five antiepileptic drug…
Received 10 July 2009 11:55 UTC; Posted 10 July 2009
Posted to: Genetics & Genomics, Neuroscience, Pharmacology, Bioinformatics
mRNA diffusion explains protein gradients in Drosophila early development
We propose a new model describing the production and the establishment of the stable gradient of the Bicoid protein along the antero-posterior axis of the embryo of Drosophila. In this model, we …
Received 06 July 2009 14:12 UTC; Posted 06 July 2009
Posted to: Developmental Biology, Bioinformatics
