Bioinformatics
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Apparent non-canonical trans-splicing is generated by reverse transcriptase in vitro
Trans-splicing, the in vivo joining of two RNA molecules, is well characterized in several groups of simple organisms but was long thought absent from fungi, plants and mammals. However, recent bio…
Received 05 February 2010 13:45 UTC; Posted 05 February 2010
Posted to: Genetics & Genomics, Bioinformatics
Modeling Three-Dimensional Spatial Regulation of Bacterial Cell Division (Dissertation)
Many important cellular processes are regulated by reaction-diffusion (RD) of molecules that takes place both in the cytoplasm and on the membrane. To model and analyze such multicompartmental proc…
Received 05 February 2010 06:38 UTC; Posted 05 February 2010
Posted to: Developmental Biology, Microbiology, Molecular Cell Biology, Bioinformatics
A Universal Carrier Test for the Long Tail of Mendelian Disease
Background: Mendelian disorders are individually rare but collectively common, forming a “long tail” of genetic disease. More than 20 million people worldwide suffer from a disease in this lo…
Received 01 February 2010 22:27 UTC; Posted 01 February 2010
Posted to: Biotechnology, Genetics & Genomics, Bioinformatics
MMsPred: a bioactivity and toxicology predictive system
In the last decade, the development and use of new methods in combinatorial chemistry and high-throughput screening has dramatically increased the number of known biologically active compounds. Par…
Received 28 January 2010 14:27 UTC; Posted 29 January 2010
Posted to: Biotechnology, Chemistry, Pharmacology, Bioinformatics
Implementation Methods for Estimating Haplotypes with Grid Computing Technology
Introduction: PHASE is a software for haplotype reconstruction and recombination rate estimation from population data and implements the methods for estimating haplotypes from population genotype d…
Received 21 January 2010 09:03 UTC; Posted 21 January 2010
Posted to: Bioinformatics
Pharmacophore Modeling and Binding Analysis for targeting Mycobacterium tuberculosis MurC ligase
Despite the availability of effective chemotherapy and the moderately protective vaccine, new anti-Tuberculosis agents are urgently needed to decrease the global incidence of Tuberculosis (TB). The…
Received 19 January 2010 06:13 UTC; Posted 19 January 2010
Posted to: Chemistry, Bioinformatics
Design of a dynamic model of genes with multiple autonomous regulatory modules by evolution in silico
A new approach to design a dynamic model of genes with multiple autonomous regulatory modules by evolution in silico is proposed. The approach is based on Genetic Algorithms, with new crossover ope…
Received 13 January 2010 23:14 UTC; Posted 14 January 2010
Posted to: Biotechnology, Developmental Biology, Genetics & Genomics, Bioinformatics, Evolutionary Biology
Metabolic constraints on the evolution of genetic codes: Did multiple ‘preaerobic’ ecosystem transitions entrain richer dialects via Serial Endosymbiosis?
A mathematical model based on Tlusty’s topological deconstruction suggests that multiple punctuated ecosystem shifts in available metabolic free energy, broadly akin to the ‘aerobic’ transition, en…
Received 12 January 2010 21:10 UTC; Posted 14 January 2010
Posted to: Ecology, Genetics & Genomics, Bioinformatics
Using Metaneva for Structuring, Managing and Retrieving Animal Data in the Cognitive Neurosciences
Contemporary cognitive neuroscience data sets are characterized by a lack of a standardized ontology, leading to shortcomings in data reports and data sharing along with possibly outdated modular m…
Received 09 January 2010 00:09 UTC; Posted 11 January 2010
Posted to: Neuroscience, Bioinformatics
ParMap, an Algorithm for the Identification of Complex Genomic Variations in Nextgen Sequencing Data
Next-generation sequencing produces high-throughput data, albeit with greater error and shorter reads than traditional Sanger sequencing methods. This complicates the detection of genomic variation…
Received 08 January 2010 20:10 UTC; Posted 12 January 2010
Posted to: Genetics & Genomics, Bioinformatics
