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What’s in an ‘is a’ link?
IntroductionSeveral researchers have demonstrated that current medical terminologies and ontologies use relations in inconsistent and ambiguous ways,1 despite Woods’ seminal work that first i…
Received 25 July 2009 15:02 UTC; Posted 27 July 2009
Posted to: Bioinformatics
The Eukaryote Genome Annotation Platform at Genoscope
The Genoscope annotation workflow for eukaryote genomes relies on evidence from ab initio gene models predictions combined with homology searches, using collections of expressed sequences – full le…
Received 24 July 2009 13:05 UTC; Posted 24 July 2009
Posted to: Genetics & Genomics, Bioinformatics
A simple clustering of the BioModels database using semanticSBML
The BioModels database contains biochemical network models in SBML format, in which the biochemical meaning of elements is specified by MIRIAM-compliant RDF annotations. We used these annotations t…
Received 20 July 2009 15:09 UTC; Posted 20 July 2009
Posted to: Bioinformatics
ECoG-based short-range recurrent stimulation techniques to stabilize tissue at risk of progressive damage: Theory based on clinical observations
We introduce theoretical concepts based on chaos control to stabilize in acute stroke the tissue at risk of progressive damage by preventing adverse effects of waves of mass neuronal depolarization…
Received 07 July 2009 16:13 UTC; Posted 08 July 2009
Posted to: Biotechnology, Neuroscience
Annotation and Curation of the Protein Data Bank
The Protein Data Bank (PDB) is the worldwide repository for experimentally determined 3D structures of biological macromolecules. Established in 1971 with just seven structures, it presently includ…
Received 27 June 2009 21:41 UTC; Posted 30 June 2009
Posted to: Bioinformatics
Analysis of Antarctic Ice Core Data (EPICA Dome C) with Flicker-Noise Spectroscopy
Evolution of Earth’s climate system over the past 800,000 years represents a complex process with successions of uneven glacial and interglacial periods. The length, amplitudes, and development of …
Received 14 June 2009 18:21 UTC; Posted 15 June 2009
Posted to: Earth & Environment
Requirements for a single cell mechanism of entorhinal “grid field” activity: role of dendritic oscillators and coupling
The responses of rat medial entorhinal cortical neurons form characteristic grid patterns as a function of the animal’s position. A recent model of grid fields proposes a mechanism based on intrins…
Received 12 June 2009 12:13 UTC; Posted 12 June 2009
Posted to: Neuroscience
Functional analysis of βC1 protein encoded by Tomato leaf curl Java virus, a monopartite begomovirus
Tomato leaf curl disease is among the most important limiting factors that affect tomato production in world wide including south East Asia. Recently, we have isolated tomato leaf curl Java virus, ...
Received 05 June 2009 15:14 UTC; Posted 08 June 2009
Posted to: Plant Biology
How do we quantify biodiversity? All the evidence in one place.
Biodiversity is a multi-dimensional concept that is represented by a large variety of measures. This complexity and lack of consistency limits the development of a coherent scientific understanding…
Received 05 June 2009 11:11 UTC; Posted 08 June 2009
Posted to: Ecology, Bioinformatics
Normalization and Matching of Chemical Compound Names
The identification of a chemical compound solely based on its name requires comprehensive chemical knowledge and often extensive searches in chemical databases. However, it is crucial for the integ…
Received 04 June 2009 16:05 UTC; Posted 05 June 2009
Posted to: Chemistry, Bioinformatics