Latest Manuscripts
Requirement of Activation for Hepatitis B Virus Infection
Although in vitro models of human hepatitis B virus replication are established, so far none could approximate infection efficiency as expected from in vivo observations. Susceptibility for HBV…
Received 25 June 2007 15:01 UTC; Posted 25 June 2007
Posted to: Microbiology
Evolution of malaria virulence in cross-generation transmission through selective immune pressure
Theoretical arguments and some mathematical models of host-parasite coevolution (e.g. [1- 6]) suggest host immunity as the driving source for the evolution of parasite virulence. Imperfect vaccines…
Received 23 June 2007 19:32 UTC; Posted 25 June 2007
Posted to: Immunology, Bioinformatics, Evolutionary Biology
Simcluster: clustering enumeration gene expression data on the simplex space
Transcript enumeration methods such as SAGE, MPSS, and sequencing-by-synthesis EST “digital northern”, are important high-throughput techniques for digital gene expression measurement. As other cou…
Received 23 June 2007 18:56 UTC; Posted 25 June 2007
Posted to: Biotechnology, Bioinformatics
A Meta-analysis of Studies on Plant Growth Rate and Allocation to Roots and Shoots
I performed a meta-analysis of studies examining the relationships among nutrient availability, plant growth rate and allocation to roots vs. shoots. Species characteristic of high fertility habits…
Received 22 June 2007 17:33 UTC; Posted 22 June 2007
Posted to: Ecology, Plant Biology
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies.
Canonical Wnt signaling is an osteo-inductive signal that promotes bone repair through acceleration of osteogenic differentiation by progenitors. Dkk-1 is a secreted inhibitor of canonical Wnt sign…
Received 20 June 2007 14:47 UTC; Posted 21 June 2007
Posted to: Biotechnology, Cancer
Characterization of Fut10 and Fut11, Putative Alpha-1-3/4 Fucosyltransferase Genes Important for Vertebrate Development
Two new, putative alpha-1-3/4 fucosyltransferases (α1-3/4 Fuc-Ts), Fuc-TX and Fuc-TXI, were identified in the vertebrate genome and transcriptome sequence databases through sequence homology-...
Received 20 June 2007 20:53 UTC; Posted 20 June 2007
Posted to: Developmental Biology, Molecular Cell Biology
Folding pathway of the B1 domain of protein G explored by a multiscale modeling
The understanding of the folding mechanisms of single domain proteins is an essential step in the understanding of protein folding in general. Recently, we developed a mesoscopic CABS protein model…
Received 20 June 2007 13:55 UTC; Posted 20 June 2007
Posted to: Molecular Cell Biology, Bioinformatics
PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.
The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive. Here we show that PIM1 contributes to the…
Received 19 June 2007 14:34 UTC; Posted 20 June 2007
Posted to: Cancer, Molecular Cell Biology
Reading the Neural Code: What do Spikes Mean for Behavior?
The present study reveals the existence of an intrinsic spatial code within neuronal spikes that predicts behavior. As rats learnt a T-maze procedural task, simultaneous changes in temporal occurre…
Received 18 June 2007 15:10 UTC; Posted 18 June 2007
Posted to: Neuroscience
Fast and Scriptable Molecular Graphics in Web Browsers without Java3D
Jmol is a free, open source molecule viewer for chemistry and biochemistry. It is cross-platform, running on Windows, Mac OS X, and Linux/Unix systems. The software consists of three parts: the Jmo…
Received 14 June 2007 14:09 UTC; Posted 14 June 2007
Posted to: Chemistry, Bioinformatics
