Latest Manuscripts
Estimation of the Multiple Testing Burden for Genomewide Association Studies of Common Variants
Genomewide association studies are an exciting strategy in genetics, recently becoming feasible. While pioneering studies are being underway, it is already clear that the analytic issue of determin…
Received 05 July 2007 14:54 UTC; Posted 05 July 2007
Posted to: Genetics & Genomics, Bioinformatics
Angiotensinergic innervation of rat and human mesenteric resistant blood vessels
In contrast to the current believe that angiotensin II (Ang II) only interacts with the sympathetic nervous system (SNS) as a circulating hormone, we document here the existence of an endogenous re…
Received 05 July 2007 07:58 UTC; Posted 05 July 2007
Posted to: Neuroscience
Review of Immunoinformatic approaches to in-silico B-cell epitope prediction
In this paper, the current state of in-silico, B-cell epitope prediction is discussed. Recommendations for improving some of the approaches encountered are outlined, along with the presentation o…
Received 05 July 2007 03:01 UTC; Posted 05 July 2007
Posted to: Immunology, Bioinformatics
The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies
Reproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the appar…
Received 02 July 2007 15:49 UTC; Posted 03 July 2007
Posted to: Biotechnology, Bioinformatics
Third-codon transversion rate-based Nymphaea basal angiosperm phylogeny—concordance with developmental evidence
Flowering plants (angiosperms) appeared on Earth rather suddenly approximately 130 million years ago and underwent a massive expansion in the subsequent 10-12 million years. Current molecular phylo…
Received 02 July 2007 13:10 UTC; Posted 02 July 2007
Posted to: Ecology, Plant Biology, Evolutionary Biology
Changes in temperature-moisture covariance could increase soil carbon loss
Soils store about 1.5×10^16 g of carbon (C), about as much as terrestrial vegetation and atmosphere combined 1. The complex interplay between factors that regulate C release from soil through respi…
Received 28 June 2007 15:57 UTC; Posted 28 June 2007
Posted to: Earth & Environment
XML in Motion from Genome to Drug
Information technology (IT) has emerged as a central to the solution of contemporary genomics and drug discovery problems. Researchers involved in genomics, proteomics, transcriptional profiling, h…
Received 28 June 2007 13:33 UTC; Posted 28 June 2007
Posted to: Chemistry, Bioinformatics
Workshop report: 1st INCF Workshop on Large-scale Modeling of the Nervous System
The goal of this workshop was to survey current demands, ongoing activities, and plans relating to development of tools for scalable neural network simulation. Areas covered included software compo…
Received 27 June 2007 12:26 UTC; Posted 27 June 2007
Posted to: Neuroscience, Bioinformatics
The nitrite anion: the key intermediate in alkyl nitrates degradative mechanism.
Alkyl nitrates, in vivo, are metabolized to yield nitric oxide, and thiol groups are considered necessary cofactors. This statement is based on studies that underline how these species potentiate…
Received 26 June 2007 07:50 UTC; Posted 26 June 2007
Posted to: Chemistry, Pharmacology
Review: Dystroglycan in the Nervous System
Dystroglycan is part of a large complex of proteins, the dystrophin-glycoprotein complex, which has been implicated in the pathogenesis of muscular dystrophies for a long time. Besides muscular de…
Received 23 June 2007 03:40 UTC; Posted 26 June 2007
Posted to: Neuroscience
