Latest Manuscripts
Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution
Surveys of protein-coding sequences for evidence of positive selection in humans and chimpanzees have flagged surprisingly few genes known to be involved in neural or nutritional processes, despite…
Received 18 June 2007 21:04 UTC; Posted 13 July 2007
Posted to: Genetics & Genomics, Bioinformatics, Evolutionary Biology
Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema.
Emphysema is a progressive lung disease characterised by loss of lung parenchyma with associated functional changes including decreased tissue elastance. Here we report beta1 integrin is a novel ta…
Received 12 July 2007 10:54 UTC; Posted 13 July 2007
Posted to: Pharmacology
Reducing the Probability of False Positive Research Findings by Pre-Publication Validation – Experience with a Large Multiple Sclerosis Database
ObjectiveWe have assessed the utility of a pre-publication validation policy in reducing the probability of publishing false positive research findings. Study design and settingThe large …
Received 12 July 2007 06:25 UTC; Posted 12 July 2007
Posted to: Neuroscience, Bioinformatics
Swine Influenza A Evolution via Recombination – Genetic Drift Reservoir
The looming influenza pandemic has focused attention1-4 on the rapid evolution of H5N1 and other human and avian serotypes. The basic tenets of influenza genetics5 define gradual changes as dr…
Received 07 July 2007 03:02 UTC; Posted 10 July 2007
Posted to: Ecology, Genetics & Genomics
Effective Sample Size: Quick Estimation of the Effect of Related Samples in Genetic Case-Control Association Analyses
Correlated samples have been frequently avoided in case-controlgenetic association studies in part because the methods for handling them are either noteasily implemented or not widely known….
Received 09 July 2007 21:41 UTC; Posted 10 July 2007
Posted to: Genetics & Genomics, Immunology
Exploiting Nonlinear Recurrence and Fractal Scaling Properties for Voice Disorder Detection
Background: Voice disorders affect patients profoundly, and acoustic tools can potentially measure voice function objectively. Disordered sustained vowels exhibit wide-ranging phenomena, from nearl…
Received 02 July 2007 21:52 UTC; Posted 09 July 2007
Posted to: Biotechnology
Quantification of Cell Movement Reveals Distinct Edge Motility Types During Cell Spreading
Actin-based motility is central to cellular processes such as migration, bacterial engulfment, and cancer metastasis, and requires precise spatial and temporal regulation of the cytoskeleton. We st…
Received 08 July 2007 07:36 UTC; Posted 09 July 2007
Posted to: Biotechnology, Molecular Cell Biology
The Freezing Rotation Illusion
The freezing rotation illusion arises when a figure is continuously rotating in front of a back and forth rotating ground. The term “freezing rotation” designates the decrease in the perceived rota…
Received 06 July 2007 07:31 UTC; Posted 08 July 2007
Posted to: Neuroscience
Epigrass: a tool to study disease spread in complex networks.
The construction of complex statial simulation models such as those used in network epidemiology, is a daunting task due to the large amount of data involved in their parameterization. Such data, w…
Received 06 July 2007 16:25 UTC; Posted 06 July 2007
Posted to: Bioinformatics
ProbCD: enrichment analysis accounting for categorization uncertainty
As in many other areas of science, systems biology makes extensive use of statistical association and significance estimates in contingency tables, a type of categorical data analysis known in this…
Received 06 July 2007 04:45 UTC; Posted 06 July 2007
Posted to: Biotechnology, Genetics & Genomics, Bioinformatics
