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Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?

Katarzyna Dunajska¹, Felicja Lwow¹, Diana Jedrzejuk², Andrzej Milewicz², Urszula Tworowska-Bardzinska³ & Lukasz Laczmanski³

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1. University School of Physical Education, Dept. of Health Promotion, Wroclaw
2. Dept. of Endocrinology, Diabetology and Isotope Treatment, Wroclaw
3. Dept. of Endocrinology, Diabetology, and Isotope Treatment, Wroclaw

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Date:

Received 05 November 2009 01:29 UTC; Posted 06 November 2009

Subjects:

Genetics & Genomics

Tags:

• CNR1 polymorphism
• Obesity
• metabolic syndrome
• postmenopausal women
• cannabinoid receptor-1

Abstract:

Objective: The aim of this study was to determine whether genetic variation at the cannabinoid receptor-1 (CNR1) locus could have an effect on adiposity, fat distribution and obesity-related metabolic disorders in Polish postmenopausal women.Design and Subjects: The A3813G, G1422A and A4895G single nucleotide polymorphisms of CNR1 were genotyped in 348 randomly selected postmenopausal women aged 50-60 years recruited from the Wroclaw city population. Measurements: CNR1 genotypes, anthropometric measures (BMI, WC, body fat distribution by DEXA) and metabolic parameters (glucose, lipid profile, insulin FIRI) were determined.Results: The 3813G allele was not significantly associated with higher body mass, BMI, WC, total fat, or fat percentage, but was associated with higher android fat deposit (2971.78 ± 1655.08 ± 2472.64 ± 1300.53, p = 0.007) and percentage of android fat (37.59 ± 8.45 vs. 35.66 ± 7.63, p = 0.062). The 1422A allele was associated with higher total fat (31587.72 ± 9161.28 g vs. 26078.26 ± 7552.14 g, p = 0.019), fat percentage (40.51 ± 5.66% vs. 37.51 ± 4.99%, p = 0.052), and percentage of android fat (40.86 ± 9.73% vs. 36.09 ± 7.70%, p = 0.047). No associations were observed for the A4895G variant.Conclusions: There is an association of variants of CNR1 with obesity-related phenotypes in Polish postmenopausal women. As CB1 is a drug target for obesity, pharmacogenetic receptor gene analysis of obesity treatment by endocannabinoid blockade may be of interest to identify the best responders.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Dunajska, Katarzyna, Lwow, Felicja, Jedrzejuk, Diana, Milewicz, Andrzej, Tworowska-Bardzinska, Urszula, and Laczmanski, Lukasz. Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.3946.1> (2009)

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