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Aven and Survivin Expression in Egyptian Acute Leukemia and Their Relation to Apoptosis

Magda Assem¹, Thorraya Abedel- ALhameid², Gihan A-Basset¹, Amany M. Hilal², Mahmoud Kamel¹, Iman Khalil¹, Nahla Alsharkawey¹ & Ayman Metwally³

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1. Clinical Pathology, National Cancer Institute, Cairo University
2. Medical Oncology, National Cancer Institute, Cairo University
3. Misr University for Science and Technology

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Document Type:

Manuscript

Date:

Received 16 September 2009 13:19 UTC; Posted 23 September 2009

Subjects:

Cancer

Tags:

• survivin
• Aven
• AML
• ALL and DNA fragmentation

Abstract:

Background: Several anti apoptotic signals have been recently identified. Aven and Survivin are broadly expressed and are conserved in mammalian species. Patients and Methods: 39 AML and 25 ALL were tested. Aven and Survivin expression were detected by RT-PCR. DNA fragmentation was carried out daily after treatment..Results: Survivin was expressed (P=0.06) more in AML (74%) than in ALL (52%). While, Aven was equally expressed in both leukemias. Patients were categorized into 3 groups based on DNA fragmentation. Absence of Aven significantly (p‹0.001) contributed to DNA fragmentation,but Survivin did not contribute as much. None of the concordant both positive Survivin and Aven were in group III (the good 5 day fragmentation, (P< 0.001). Survivin was statistically related to CD7 expression (P<0.001) in AML only. There was a significant dissociation between Aven and Survivin in AML (p=0.03) and near significant dissociation in ALL (p=0.07). Conclusion: Aven seems to be more important as an inhibitor of apoptosis than survivin in acute leukemia. The presence of both confers a survival disadvantage and a significantly worse DNA fragmentation pattern suggesting a synergistic inhibition of apoptosis. The highly significant relation between CD7 and survivin expression might suggest their involvement in a common signal transduction pathway.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Assem, Magda, Abedel- ALhameid, Thorraya, A-Basset, Gihan, Hilal, Amany, Kamel, Mahmoud, Khalil, Iman, Alsharkawey, Nahla, and Metwally, Ayman. Aven and Survivin Expression in Egyptian Acute Leukemia and Their Relation to Apoptosis. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.3771.1> (2009)

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