0 votes

Polymorphisms of TSER and MTHFR are associated with prognosis of fluoropyrimidine-based therapy in colorectal cancer patients

Jong Woo Kim¹, Jae Ho Lee², Seung Ho Hong³, Su Jin Bae², Young Do Kwon², Doyeun Oh⁴ & Nam Keun Kim²

Correspondence: (Login to view email address)

1. Institute for Clinical Research and Department of Surgery, CHA University, Seongnam, South Korea
2. Institute for Clinical Research, CHA University, Seongnam, South Korea
3. Department of Science Education, Teachers College, Jeju National University
4. Department of Internal Medicine, CHA University, Seongnam, South Korea

DOC (408.5 KB) PDF (131.1 KB)

Document Type:

Manuscript

Date:

Received 11 September 2009 00:36 UTC; Posted 11 September 2009

Subjects:

Cancer, Genetics & Genomics

Tags:

• Methylenetetrahydrofolate reductase (MTHFR); thymidylate synthase enhance region (TSER); colorectal cancer
• prognosis; polymorphism

Abstract:

This study was designed to investigate the influence of TSER and MTHFR polymorphisms on the clinical outcomes of patients with colorectal cancer receiving 5-FU-based chemotherapy. Genomic DNA was isolated from 103 frozen or paraffin-embedded tissues of colorectal cancer patients. The genotypes of two common polymorphisms were determined by PCR-RFLP. Patient prognoses were compared with genotype groups and analyzed according to tumor location. Polymorphisms of TSER and MTHFR 677C>T were not significantly associated with clinicopathological factors. There were no differences in prognosis between genotypes or functional groups when the TSER and MTHFR groups were considered separately. However, analysis of combined genotypes of the TSER and the MTHFR 677C>T polymorphisms were associated with the survival rate of colorectal cancer patients who received 5-FU-based chemotherapy (p=0.028). Prognosis of colorectal cancer patients was significantly different between proximal colon and distal colon cancers (p=0.002). However, prognosis did not receive any effect of the combined genotype when analyzed according to tumor location, such as proximal and distal colon cancer. The combined TSER and MTHFR 677C>T genotypes can be prognostic factors in colorectal cancer, where gene-gene interactions between the genotypes may occur.

Discussion

Votes:

0 votes

(Login to vote)

Comments:

0 comments

(Login to post a comment)

Share:

(Login to share with a colleague)

Additional information

License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Kim, Jong Woo, Lee, Jae Ho , Hong, Seung Ho, Bae, Su Jin, Kwon, Young Do, Oh, Doyeun, and Kim, Nam Keun. Polymorphisms of TSER and MTHFR are associated with prognosis of fluoropyrimidine-based therapy in colorectal cancer patients . Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.3741.1> (2009)

Version info:

Other versions of this document in Nature Precedings

None.

Other versions of this document elsewhere on the web

None known.

Submit a new version link