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The joys and perils of recombination – The hotspot conversion paradox and the evolution of recombination

Mario Pineda-Krch¹ and Rosemary J. Redfield²

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1. Centre for Mathematical Biology, University of Alberta
2. Department of Zology, University of British Columbia

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Date:

Received 21 August 2009 20:11 UTC; Posted 21 August 2009

Subjects:

Genetics & Genomics, Evolutionary Biology

Tags:

• yeast
• double-strand-break
• gene conversion
• hot-spots
• crossover interference
• meiosis

Abstract:

The contradiction between the long-term persistence of the chromosomal hotspots that initiate meiotic recombination and the self-destructive mechanism by which they act strongly suggests that our understanding of recombination is incomplete. To investigate the requirements for hotspot persistence, Rosemary Redfield and I developed a computer simulation model, hotspot, of their activity and its evolutionary consequences.

Presented at:

Lab meeting (SOWD) at the Department of Zoology, University of British Columbia, 20 March 2003

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Pineda-Krch, Mario and Redfield, Rosemary. The joys and perils of recombination – The hotspot conversion paradox and the evolution of recombination . Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2009.3636.1> (2009)

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