Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse
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- Dept. of Experimental Neurology and Center for Stroke Research (CSB), Charite University Medicine Berlin, Germany
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- Document Type:
- Manuscript
- Date:
- Received 28 July 2009 16:54 UTC; Posted 28 July 2009
- Subjects:
- Neuroscience
- Abstract:
Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control in randomized clinical trials and will hopefully be widely adopted by preclinical stroke research in the near future. Increasingly, funding bodies and review boards overseeing animal experiments are taking a proactive stance, and demand auditable quality control measures in preclinical research. Every good quality control system is based on its SOPs. This article introduces the concept of quality control and presents for the first time an SOP in experimental stroke research.
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- License:
- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Dirnagl, Ulrich and Group, Members of the MCAO-SOP. Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.3492.1> (2009)
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