Explaining microbial population genomics through phage predation
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- División de Microbiología, Universidad Miguel Hernández, Campus de San Juan, Alicante, Spain
- Department of Biology, San Diego State University, California, USA
- University of Ljubljana : Department of Biology : Vecna pot 111 : 1000 Ljubljana : Slovenia
- Department of Biology, University of Bergen, Bergen, Norway
- Área Genómica y Salud, Centro Superior de Investigación en Salud Pública, Valencia, Spain
This manuscript is a preprint. A published version is available at:
10.1038/nrmicro2235 (Peer Reviewed) Published in Nature Reviews Microbiology 7, 828-836 (November 2009).- Document Type:
- Manuscript
- Date:
- Received 28 July 2009 11:18 UTC; Posted 29 July 2009
- Subjects:
- Microbiology
- Abstract:
The remarkable diversity of genes within the pool of prokaryotic genomes belonging to the same species or pan-genome is difficult to reconcile with the widely accepted paradigm which asserts that periodic selection within bacterial populations would regularly purge genomic diversity by clonal replacement. Recent evidence from metagenomics indicates that even within a single sample a large diversity of genomes can be present for a single species. We have found that much of the differential gene content affects regions that are potential phage recognition targets. We therefore propose the operation of Constant-Diversity dynamics in which the diversity of prokaryotic populations is preserved by phage predation. We provide supporting evidence for this model from metagenomics, mathematical analysis and computer simulations. Periodic selection and phage predation dynamics are not mutually exclusive; we compare their predictions to indicate under which ecological circumstances each dynamics could predominate.
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- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Rodriguez-Valera, Francisco, Martín-Cuadrado, Ana-Belén, Rodriguez-Brito, Beltrán, Pasic, Lejla, Thingstad, T. Frede, Rohwer, Forest, and Mira, Alex. Explaining microbial population genomics through phage predation. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2009.3489.1> (2009)
- Version info:
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Published version:
10.1038/nrmicro2235 (Peer Reviewed) Published in Nature Reviews Microbiology 7, 828-836 (November 2009). -
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