Common Transactivation Motif 9aaTAD recruits multiple general co-activators TAF9, MED15, CBP and p300
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- Department of Genetics, Max F. Perutz Laboratories
- Document Type:
- Manuscript
- Date:
- Received 03 November 2009 12:30 UTC; Posted 05 November 2009
- Subjects:
- Genetics & Genomics
- Abstract:
More than 2000 transcription factors are involved in the human gene regulation to provide cellular function and development. Transactivation domain, TAD, mediates the interaction of transcription factors with general transcriptional co-activators such as TAF9, MED15, CBP and p300. Recently reported NMR-data for interactions of these co-activators with transcription factors reveal tightly binding of KIX and TAZ domains to common 9aaTAD motif. Nine-amino-acid Trans-Activation Domain, 9aaTAD, defines a transactivation domain common to a large super-family of eukaryotic transcription factors represented in yeast by Gal4, Oaf1, Pdr1, Rtg3, Pho4, Gln3, Gcn4 and in mammals by p53, E2A, NFAT, NFkB, HSF1, NF-IL6, MLL, EBNA2, VP16. The 9aaTAD family was derived from the transcription factor Oaf1 and its close orthologs Gal4, Pdr1, Leu3, Tea1 and Cha4.
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- This document is licensed to the public under the Creative Commons Attribution 3.0 License
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Piskacek, Martin. Common Transactivation Motif 9aaTAD recruits multiple general co-activators TAF9, MED15, CBP and p300. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2009.3488.2> (2009)
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Other versions of this document in Nature Precedings
Version number Document title Date v1 Posted 28 July 2009 Other versions of this document elsewhere on the web
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