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Independent elaboration of steroid hormone signaling pathways in Metazoans

Gabriel V. Markov¹, Raquel Tavares², Chantal Dauphin-Villemant³, Barbara A. Demeneix⁴, Michael E. Baker⁵ & Vincent Laudet¹

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1. Institut de Génomique Fonctionnelle de Lyon; Université de Lyon; Université Lyon 1; CNRS; INRA; Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon Cedex 07, France
2. Université de Lyon, F-69000, Lyon ; Université Lyon 1 ; CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, F-69622, Villeurbanne, France
3. Unité Mixte de Recherche 7622, Biologie du Developpement, Equipe Biogenèse des Signaux hormonaux, Centre National de la Recherche Scientifique ¬ Université Paris 6
4. Unité Mixte de Recherche 7221- Evolution des Régulations Endocriniennes. Muséum National d'Histoire Naturelle, Paris, France
5. Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0693

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Document Type:

Manuscript

Date:

Received 25 June 2009 20:55 UTC; Posted 26 June 2009

Subjects:

Cancer, Developmental Biology, Bioinformatics, Earth & Environment, Evolutionary Biology

Tags:

• cyp450
• xenobiotics
• xenoestrogens
• vertebrate evolution
• nuclear receptors
• steroidogenesis

Abstract:

Steroid hormones regulate many physiological processes in vertebrates, nematodes and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well understood. In contrast, the origin and evolution of steroid ligands remain mysterious although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole Metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the three main Bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Markov, Gabriel, Tavares, Raquel, Dauphin-Villemant, Chantal, Demeneix, Barbara, Baker, Michael, and Laudet, Vincent. Independent elaboration of steroid hormone signaling pathways in Metazoans. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.3374.1> (2009)

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