0 votes

First Hematological Signals of Latent Anemia to Aging Population

Aurelian Udristioiu¹

Correspondence: (Login to view email address)

1. Emergency County Hospital Targu Jiu

PPT (646 KB) PDF (574.7 KB)

Download:

PDF (574.7 KB)

Embed:

License:

Document Type:

Presentation

Date:

Received 26 May 2009 08:32 UTC; Posted 26 May 2009

Subjects:

Chemistry

Tags:

• AURICA
• Latent Anemia
• Aging

Abstract:

Anemia is an independent risk factor for morbidity and mortality in an array of disorders common to seniors including cancer, renal diseases and heart diseases. The aim of this study was to identify the first hematological signals of latent anemia to aging population using as screening the hematological aspects of cells from peripheral blood and additional tests, establishing the etiology of anemia in the elderly.

Method: Additional to level of hemoglobin(HGB) and hematocrit (HCT) have been included Hematological Indexes( MCV, HCV, MCHC ), red cell distribution width,(RDW), reticulocyte count (RET), serum iron (SI), total iron binding capacity,(TIBC), transferrin saturation index, (TSI), serum ferritin( SF), on an study of 140 adult hospitalized patients, in wars with chronic diseases males and females with ages past 65 years.

Results: Anemia of chronic diseases (ACD) is more common in the elderly than other group.
In ACD correlation of hematological testes was following: 32 % with normal HGB, HCT and normal hematological indexes, 21.5 % with only MCV or HCV decreased, 22.5 % patients with HB in value 10.8 g/dl for women and 11.08 g/dl form men, 15 % patients with HB 9.8-10.6g/d L and 9% patients with HB 7.8-9.6, g/d L (mean SD=2,2 ); average number of Reticulocytes =1.2%; Corrected Index Ret = 0.6%; Production Index Reticulocytes, (PIR) = 1.4, meaning the hypo-regenerative anemia with globular value, GV =1.2. Precision: CV < 2% for RBC, CV < 1% for HB and CV < 2% for HCT. Accuracy: R > 0.95 for RBC, HGB and HCT.

In this study was observed a higher prevalence of anemia in elderly men than in women. Anemia of renal disease is considered to be a distinct form of anemia and is typical due to decreased EPO production in 20 percent from normal value to adult persons.

Discussion: Elderly anemic patients fail to show increases in erythrocytes progenitors and reticuloculocytes as a result of chronic stress along life. In some cases, the presence of anemia may reflect an underling or undetected medical condition.

Conclusions: Most anemic adults are asymptomatic until HGB fall below normal values. For this reason a routine anemia screening should be recommended by HB, HCT and MCV, HCV, MCHC to persons with age past >_65 year.

Presented at:

Anti-Aging Congress AMAA 2009, Europe Hotel, Eforie Notd, ROMANIA, 22 May 2009

Discussion

Votes:

0 votes

(Login to vote)

Comments:

0 comments

(Login to post a comment)

Share:

(Login to share with a colleague)

Additional information

License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Udristioiu, Aurelian. First Hematological Signals of Latent Anemia to Aging Population . Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2009.3285.1> (2009)

Version info:

Other versions of this document in Nature Precedings

None.

Other versions of this document elsewhere on the web

None known.

Submit a new version link