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Spontaneous glomerular deposition of immunoglobulins for ACE (Angiotensin Converting Enzyme) induces spontaneous nephropathy in diabetogenic rats

Seikoh Nishida¹, Tamaki Sasaki², Yasushi Hirokawa¹, Michihiro Matsuki¹ & Tsutomu Nohno³

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1. Division of Endocrinology, Kawasaki Medical School
2. Division of Nephrology, Kawasaki Medical School
3. Department of Molecular Biology, Kawasaki Medical School

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Document Type:

Manuscript

Date:

Received 23 May 2009 07:07 UTC; Posted 26 May 2009

Subjects:

Immunology

Tags:

• ACE
• OLETF rat
• spontaneous glomerular deposition
• angiotensin converting enzyme
• autoantibodies
• immunoglobulins
• diabetes
• glomerulopathy
• nephropathy

Abstract:

We first discovered autoantibodies to ACE (angiotensin converting enzyme) in patients with type 2 diabetes mellitus¹. The antibodies were positive for 64.5% of the patients with diabetes and were positive in 83.3% in the early stage of clinical diabetic nephropathy. In addition, in genetically diabetogenic OLETF (Otsuka Long-Evans Tokushima Fatty) rats², one of the characteristics of which strain is spontaneous nephropathy resembling those of human type 2 diabetes, and in control LETO rats², immunization with rabbit lung ACE developed glomerulopathy similar to that seen in diabetics³. Also, in normal New Zealand white rabbits, immunization with the rabbit lung ACE induced glomerular changes similar to those seen in diabetic nephropathy³. In this study, renal tissues identical to those examined in research of diabetic nephropathy by PAS staining and electron microscope in preceding study³, were examined by immunostaining methods, only to prove that the diabetic glomerular changes may occur by immunization with ACE, not by non-specific responses to ACE, in non-diabetogenic rats and rabbits.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Nishida, Seikoh, Sasaki, Tamaki, Hirokawa, Yasushi, Matsuki, Michihiro, and Nohno, Tsutomu. Spontaneous glomerular deposition of immunoglobulins for ACE (Angiotensin Converting Enzyme) induces spontaneous nephropathy in diabetogenic rats. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.3275.1> (2009)

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