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Variation in PNPLA3 is associated with outcomes in alcoholic liver disease

Chao Tian¹, Renee P. Stokowski¹, David Kershenobich², Dennis G. Ballinger³ & David A. Hinds¹

Correspondence: (Login to view email address)

1. Perlegen, 2021 Stierlin Court, Mountain View, CA 94043, USA
2. Departmento de Medicina Experimental, Facultad de Medicina de UNAM, Mexico D.F.
3. Complete Genomics, 2071 Stierlin Court, Mountain View, CA 94043, USA

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Date:

Received 05 October 2009 19:14 UTC; Posted 06 October 2009

Subjects:

Genetics & Genomics

Tags:

• association study
• SNP
• cirrhosis
• Human

Abstract:

Two recent genome-wide association studies have described associations of SNP variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels in population based cohorts. We investigated the contributions of these variants to clinical outcomes in Mestizo subjects with a history of excessive alcohol consumption. We show that non-synonymous variant rs738409[G] (I148M) in PNPLA3 is strongly associated with alcoholic liver disease and progression to alcoholic cirrhosis (unadjusted OR = 2.25, P = 1.7×10^-10; ancestry-adjusted OR = 1.79, P = 1.9×10^-5).

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Tian, Chao, Stokowski, Renee, Kershenobich, David, Ballinger, Dennis, and Hinds, David. Variation in PNPLA3 is associated with outcomes in alcoholic liver disease. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.3254.2> (2009)

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Version number	Document title	Date
v1	Posted 22 May 2009

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