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Cancer Biology Data Curation at the Mouse Tumor Biology Database (MTB)

Debra M. Krupke¹, Dale A. Begley¹, Steven B. Neuhauser¹, Joel E. Richardson¹, John P. Sundberg¹, Carol J. Bult¹ & Janan T. Eppig¹

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1. The Jackson Laboratory

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Document Type:

Poster

Date:

Received 13 May 2009 15:27 UTC; Posted 13 May 2009

Subjects:

Cancer, Genetics & Genomics, Bioinformatics

Tags:

• mouse models
• cancer genetics
• database
• pathology
• cytogenetics
• bioinformatics

Abstract:

Many advances in the field of cancer biology have been made using mouse models of human cancer. The Mouse Tumor Biology (MTB, http://tumor.informatics.jax.org) database provides web-based access to data on spontaneous and induced tumors from genetically defined mice (inbred, hybrid, mutant, and genetically engineered strains of mice). These data include standardized tumor names and classifications, pathology reports and images, mouse genetics, genomic and cytogenetic changes occurring in the tumor, strain names, tumor frequency and latency, and literature citations.

Although primary source for the data represented in MTB is peer-reviewed scientific literature an increasing amount of data is derived from disparate sources. MTB includes annotated histopathology images and cytogenetic assay images for mouse tumors where these data are available from The Jackson Laboratory’s mouse colonies and from outside contributors. MTB encourages direct submission of mouse tumor data and images from the cancer research community and provides investigators with a web-accessible tool for image submission and annotation.

Integrated searches of the data in MTB are facilitated by the use of several controlled vocabularies and by adherence to standard nomenclature. MTB also provides links to other related online resources such as the Mouse Genome Database, Mouse Phenome Database, the Biology of the Mammary Gland Web Site, Festing’s Listing of Inbred Strains of Mice, the JAX® Mice Web Site, and the Mouse Models of Human Cancers Consortium’s Mouse Repository.

MTB provides access to data on mouse models of cancer via the internet and has been designed to facilitate the selection of experimental models for cancer research, the evaluation of mouse genetic models of human cancer, the review of patterns of mutations in specific cancers, and the identification of genes that are commonly mutated across a spectrum of cancers.

MTB is supported by NCI grant CA089713.

Collection:

3rd International Biocuration Conference

Presented at:

3rd International Biocuration Conference, 18 April 2009

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Additional information

License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Krupke, Debra, Begley, Dale, Neuhauser, Steven, Richardson, Joel, Sundberg, John, Bult, Carol, and Eppig, Janan. Cancer Biology Data Curation at the Mouse Tumor Biology Database (MTB). Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2009.3245.1> (2009)

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