IUPHAR-DB: An Expert-Curated, Peer-Reviewed Database of Receptors and Ion Channels
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- Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, EH16 4TJ, UK
- Institute of Evolutionary Biology, University of Edinburgh, Ashworth Labs, Edinburgh, EH9 3JT, UK
- International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification
- Document Type:
- Poster
- Date:
- Received 07 May 2009 15:50 UTC; Posted 07 May 2009
- Subjects:
- Pharmacology, Bioinformatics
- Abstract:
The International Union of Basic and Clinical Pharmacology database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 non-sensory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated ion channel subunits encoded by the human, rat and mouse genomes. These genes represent the targets of about a third of currently approved drugs and are a major focus of drug discovery and development programs in the pharmaceutical industry. Individual gene pages provide a comprehensive description of the genes and their functions, with information on protein structure, ligands, expression patterns, signaling mechanisms, functional assays and biologically important receptor variants (e.g. single nucleotide polymorphisms and splice variants). The phenotypes resulting from altered gene expression (e.g. in genetically altered animals) and genetic mutations are described. Links are provided to bioinformatics resources such as NCBI RefSeq, OMIM, PubChem, human, rat and mouse genome databases. Recent developments include the addition of ligand-centered pages summarising information about unique ligand molecules in IUPHAR-DB. IUPHAR-DB represents a novel approach to biocuration because most data are provided through manual curation of published literature by a network of over 60 expert subcommittees coordinated by NC-IUPHAR. Data are referenced to the primary literature and linked to PubMed. The data are checked to ensure accuracy and consistency by the curators, added to the production server using custom-built submission tools and peer-reviewed by NC-IUPHAR, before being transferred to the public database. Data are reviewed and updated regularly (at least biennially). Other website features include comprehensive database search tools, online and downloadable gene lists and links to recent publications of interest to the field, such as reports on receptor-ligand pairings. The database is freely available at http://www.iuphar-db.org. Curators can be reached at curators [at] iuphar-db.org. We thank British Pharmacological Society, UNESCO (through the ICSU Grants Programme), Incyte, GlaxoSmithKline, Novartis, Servier and Wyeth for their support.
- Collection:
- 3rd International Biocuration Conference
- Presented at:
- 3rd International Biocuration Conference, 16 April 2009
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Additional information
- License:
- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Sharman, Joanna, Hale, Valerie, Hills, Rebecca, Rosser, Edward, Jones, Martin, Greenhill, Stuart, Harmar, Anthony, and IUPHAR, NC -. IUPHAR-DB: An Expert-Curated, Peer-Reviewed Database of Receptors and Ion Channels. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2009.3230.1> (2009)
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