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Worm Annotation in the UniProt Knowledgebase (UniProtKB)

Duncan J. Legge¹ and UniProt Consortium²

Correspondence: (Login to view email address)

1. EMBL-EBI
2. European Bioinformatics Institute (EMBL-EBI), Swiss Institute of Bioinformatics (SIB) and Protein Information Resource (PIR)

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Document Type:

Poster

Date:

Received 23 April 2009 11:47 UTC; Posted 23 April 2009

Subjects:

Bioinformatics

Tags:

• Caenorhabditis
• elegans
• uniprot
• data
• curation
• worm
• WormBase
• annotation
• EBI
• UniProtKB
• crosslinking
• EMBL
• literature
• protein
• database
• bank
• nematode
• manual
• Swiss-Prot

Abstract:

The nematode worm, Caenorhabditis elegans, was the first multicellular organism to be sequenced. Its genome was published in 1998, providing an impetus for gene and protein annotation. Recently, the genome of C. briggsae has been sequenced. This has given bioinformaticans the opportunity to study comparative genomics between two highly similar organisms. Currently, there are 12 species of Caenorhabditis in UniProtKB and over 700 nematode species, including some of interest to parasitology. Functional and sequence annotation from literature and sequence analysis tools are included in each curated record. C. elegans has a relatively small genome size, short life span and a transparent body, making it ideal for knock-out/RNAi studies. Thus many C. elegans UniProtKB entries have characterization details in the newly introduced DISRUPTION PHENOTYPE comment. Many more worm genome sequencing projects are underway, three of which involve species from the Caenorhabditis genus (C. brenneri, C. japonica and C.remanei). We look forward to working with this influx of data and continuing our close collaboration with WormBase.

Collection:

3rd International Biocuration Conference

Presented at:

3rd International Biocuration Conference, 16 April 2009

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Additional information

License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Legge, Duncan and Consortium, UniProt. Worm Annotation in the UniProt Knowledgebase (UniProtKB). Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2009.3157.1> (2009)

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