Learning alters theta-nested gamma oscillations in inferotemporal cortex
Correspondence: (Login to view email address)
- Cognitive and Systems Neuroscience Group, The Babraham Institute
- Mathematics Department, Zhejiang Normal University
- Department of Computer Science, University of Warwick
- Document Type:
- Manuscript
- Date:
- Received 28 April 2009 14:14 UTC; Posted 28 April 2009
- Subjects:
- Neuroscience
- Abstract:
How coupled brain rhythms influence cortical information processing to support learning is unresolved. Local field potential and neuronal activity recordings from 64- electrode arrays in sheep inferotemporal cortex showed that visual discrimination learning increased the amplitude of theta oscillations during stimulus presentation. Coupling between theta and gamma oscillations, the theta/gamma ratio and the regularity of theta phase were also increased, but not neuronal firing rates. A neural network model with fast and slow inhibitory interneurons was developed which generated theta nested gamma. By increasing N-methyl-D-aspartate receptor sensitivity similar learning-evoked changes could be produced. The model revealed that altered theta nested gamma could potentiate downstream neuron responses by temporal desynchronization of excitatory neuron output independent of changes in overall firing frequency. This learning-associated desynchronization was also exhibited by inferotemporal cortex neurons. Changes in theta nested gamma may therefore facilitate learning-associated potentiation by temporal modulation of neuronal firing.
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- License:
- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Kendrick, Keith, Zhan, Yang, Fischer, Hanno, Nicol, Alister, Zhang, Xuejuan, and Feng, Jianfeng. Learning alters theta-nested gamma oscillations in inferotemporal cortex. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.3151.2> (2009)
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Other versions of this document in Nature Precedings
Version number Document title Date v1 Posted 24 April 2009 Other versions of this document elsewhere on the web
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