Small Colony Variants and Senescent Bacteria
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- University of Maryland
- Document Type:
- Presentation
- Date:
- Received 21 April 2009 14:40 UTC; Posted 22 April 2009
- Subjects:
- Microbiology, Pharmacology
- Abstract:
Small colony variants (SCVs) are bacterial subpopulation that grow slowly and form smaller colonies. They have been described for a wide range of bacterial species, but most extensively studied for Staphylococci. They are considered as mutants that are auxotrophic to hemin, thiamine or thymidine. In the presence of auxotrophic agents, they revert to normal growth. They are tolerant to many antibiotics and are implicated in chronic and persistent infections. In this presentation, it is proposed that most of them are normal senescent bacteria that do not revert in the presence of auxotrophic agents. SCVs can explain the concentration dependent killing property, long post-antibiotic effect and increased resistance to aminoglycosides.
- Presented at:
- National Symposium on Antimicrobial Resistance & Drug Discovery, Coimbatore, 09 September 2009
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Additional information
- License:
- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
-
Jacob, Jaison. Small Colony Variants and Senescent Bacteria. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2009.3118.1> (2009)
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