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Validated, Ultra Violet Spectroscopy Method for the Dissolution Study of Mycophenolate Mofetil Immediate Release 500mg Tablets

Surajpal Verma¹, Ozair Alam¹, Pooja Mullick¹, Nadeem Siddiqui¹ & Suroor Khan¹

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1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi

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Date:

Received 19 April 2009 05:06 UTC; Posted 22 April 2009

Subjects:

Chemistry

Tags:

• HPLC
• Mycophenolate mofetil
• absorbance
• dissolution

Abstract:

A simple, selective and precise dissolution method was developed and validated for the Mycophenolate mofetil immediate release tablets. The method employed dissolution medium 0.1N HCl (pH1.2) and volume 900ml with USP-II apparatus (Paddle). Detection was made by measuring the absorbance on UV at the λ_max 250nm. The method show the linearity in the range of conc. 5μg/ml to 40μg/ml with r²=0.999. The method is also validated as per International Conference of Harmonization guidelines. The method showed the specificity with standard deviation 0.00. The method is repeatable, selective and accurate for the dissolution study of Mycophenolate mofetil immediate release tablets.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Verma, Surajpal, Alam, Ozair, Mullick, Pooja, Siddiqui, Nadeem, and Khan, Suroor. Validated, Ultra Violet Spectroscopy Method for the Dissolution Study of Mycophenolate Mofetil Immediate Release 500mg Tablets. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.3084.1> (2009)

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