0 votes

Aging as a consequence of misrepair—A novel theory of aging

Jicun Wang¹, Thomas Michelitsch², Arne Wunderlin³ & Ravi Mahadeva¹

Correspondence: (Login to view email address)

1. Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom
2. Institut Jean le Rond d’Alembert CNRS UMR 7190, Université Pierre et Marie Curie (Paris 6), 4 Place Jussieu, 75252 Paris cedex 05, France
3. Institut für Theoretische Physik, Pfaffenwaldring 57/4, D-70550 Stuttgart, Germany

DOC (99.5 KB) PDF (90.5 KB)

Document Type:

Manuscript

Date:

Received 26 March 2009 23:41 UTC; Posted 30 March 2009

Subjects:

Developmental Biology, Evolutionary Biology

Tags:

• Aging
• Misrepair accumulation
• longevity
• damage

Abstract:

It is now increasingly realized that the underlying mechanisms which govern aging is a complex interplay of genetic regulation and damage accumulation. Aging as a result of accumulation of ‘faults’ on cellular and molecular levels, has been proposed in the damage (fault)-accumulation theory by Kirkwood 2006. However, this theory fails to explain some aging phenotypes such as fibrosis and premature aging, since terms such as ‘damage’ and ‘fault’ are not specified. Therefore we introduce here a specification of the underlying mechanism and arrive at a novel theory: aging of the body is a result of the accumulation of Misrepair of tissue. It emphasizes: a) it is Misrepair, not the original damage, that accumulates and leads to aging; and b) aging can occur at different levels, however aging of the body takes place at least on the tissue level, but not necessarily on cellular/molecular level. The novel concept of Misrepair which is introduced here unifies the understanding of the roles of environmental damage, repair, gene regulation, and multicellular structure in the aging process. The Misrepair-accumulation theory which is introduced here gives also explanations for the aging phenotypes, premature aging, and the difference of longevity in different species and is consistent with the point of view of physical theory of complex systems.

Discussion

Votes:

0 votes

(Login to vote)

Comments:

0 comments

(Login to post a comment)

Share:

(Login to share with a colleague)

Additional information

License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Wang, Jicun, Michelitsch, Thomas, Wunderlin, Arne, and Mahadeva, Ravi. Aging as a consequence of misrepair—A novel theory of aging. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.2988.1> (2009)

Version info:

Other versions of this document in Nature Precedings

Version number	Document title	Date
v3	Posted 17 June 2009
v2	Posted 06 April 2009

Other versions of this document elsewhere on the web

• http://fr.arxiv.org/abs/0904.0575 : Cite as: arXiv:0904.0575v1 [q-bio.TO]

Submit a new version link