Evaluation of effective parameters on fabrication of BSA nanoparticles
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- Noshirvan University of Technology, Chemical Engineering
- Noshirvan University of Technology,
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- Document Type:
- Manuscript
- Date:
- Received 22 March 2009 16:37 UTC; Posted 31 March 2009
- Subjects:
- Biotechnology, Developmental Biology, Evolutionary Biology
- Abstract:
Coacervation technique was implemented in fabrication of BSA nanoparticle for the purpose of drug delivery system. Nanoparticle was purified with 48,800 g centrifuge, and then followed by dialysis, micro and ultra filtration. The fabricated nanoparticles were subjected to physical, morphological and biochemical characterization. The analyzed samples by SEM and AFM proved the semi-spherically shape of the particles whilst the size distribution was measured by photon correlation spectroscopy. Fourier transforms infra-red spectroscopy (FTIR) spectrum indicated that the fabricated nanoparticles were pure. The impact of various parameters upon the particle size was extensively investigated. The concentration of glutaraldehyde at fixed temperature had absolutely no significant effect on the size of particles. The affecting parameter was modeled to predict the size of nanoparticle. At low temperature (4{degree sign}C), the nanoparticle size of 89.3nm was fabricated with pure BSA concentration of 20 mg.ml-1.
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- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Rahimnejad, Mostafa, najafpour, Ghasem, and Jahanshahi, Mohsen. Evaluation of effective parameters on fabrication of BSA nanoparticles. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.2966.1> (2009)
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