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Delayed-Type hypersensitivity to latex: Computational prediction of MHC class II epitopes on latex allergens

Bell R. Eapen¹

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1. Kaya skin clinic

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Document Type:

Manuscript

Date:

Received 06 March 2009 10:17 UTC; Posted 06 March 2009

Subjects:

Immunology, Bioinformatics

Tags:

• Natural Rubber Latex
• MHC Class II

Abstract:

Delayed type hypersensitivity to natural rubber latex is rare compared to IgE mediated immediate reactions. Binding of allergens to MHC Class II is a crucial step in the presentation of antigens to CD4+ T Cells responsible for delayed reactions. Computational prediction of MHC class II epitopes on thirteen known latex allergens using SMM-align method revealed strong binding with several alleles. This shows that latex allergens are capable of initiating delayed type hypersensitivity in susceptible individuals.

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License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Eapen, Bell. Delayed-Type hypersensitivity to latex: Computational prediction of MHC class II epitopes on latex allergens . Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.2931.1> (2009)

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• http://www.gulfdoctor.net/bioblog/2008/08/delayed-type-hypersensitivity-to-latex.html :

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