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Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals

Hailong Zhou¹, Ying Qu¹ & Qinzhao Xue¹

Correspondence: (Login to view email address)

1. Yantai Institute of Coastal Zone Research for Sustainable Development, Chinese Academy of Sciences

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Document Type:

Manuscript

Date:

Received 05 March 2009 16:39 UTC; Posted 17 March 2009

Subjects:

Bioinformatics, Evolutionary Biology

Tags:

• Synonymous nucleotide substitutions
• AhR pathway
• aryl hydrocarbon receptor
• Nonsynonymous nucleotide substitutions
• Persistent organic pollutants
• CYP1A
• dS
• POPs
• transcription factor
• dN

Abstract:

Phylogenetic analysis of AhR pathway genes and their evolutionary rate variations were studied on aquatic animals. The gene sequences for the proteins involved in this pathway were obtained from major phylogenetic groups of mollusc, amphibian, fish and aquatic mammal. These genes were distributed under four major steps of toxicology regulation: formation of cytosolic complex, translocation of AhR, heterodimerization of AhR and induction of CYP1A. The NJ, MP and ML algorithm were used on protein coding DNA sequences to deduce the evolutionary relationship for the respective AhR pathway gene among different aquatic animals. The rate of nonsynonymous nucleotide substitutions per nonsynonymous site (d_N) and synonymous nucleotide substitutions per synonymous site (d_S) were calculated for different clade of the respective phylogenetic tree for each AhR pathway gene. The phylogenetic analysis suggests that evolutionary pattern of AhR pathway genes in aquatic animals is characterized mainly by gene duplication events. The d_N values indicate that AhR pathway genes are well conserved in aquatic animals, except for CYP1A gene. Furthermore, the d_N value indicates that AhR pathway genes are less conserved in fish than in any other aquatic animals, and they likely go through an adaptive evolution within aquatic animals.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Zhou, Hailong, Qu, Ying, and Xue, Qinzhao. Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.2928.1> (2009)

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