Optimal control circuitry design for the digital p53 dynamics in cancer cell and apoptosis
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- University of Palermo, Dept. of Structural, Aerospace Engineering and Geotechnics
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- Document Type:
- Manuscript
- Date:
- Received 13 February 2009 00:02 UTC; Posted 17 February 2009
- Subjects:
- Biotechnology, Cancer, Developmental Biology
- Abstract:
Experimental work and theoretical models deduce a “digital” response of the p53 transcription factor when genomic integrity is damaged. The mutual influence of p53 and its antagonist, the Mdm2 oncogene, is closed in feedback. This paper proposes an aerospace architecture for translating the p53/Mdm2/DNA damage network into a digital circuitry in which the optimal control theory is applied for obtaining the requested dynamic evolutions of some considered cell species for repairing a DNA damage. The purpose of this paper is not to improve the analysis of the actual mathematical models but to demonstrate the usefulness of such digital circuitry design capable to predict and detect the cell species dynamics for finding more information regarding the inner mechanism of the cell components.The cell fate is newly conceived by the modified pulsing mechanism of p53 and other apoptotic species when the digital optimal control is applied to an apoptosis wiring diagram.
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- License:
- This document is licensed to the public under the Creative Commons Attribution 3.0 License
- How to cite this document:
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Ardito Marretta, Rosario. Optimal control circuitry design for the digital p53 dynamics in cancer cell and apoptosis. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.2870.1> (2009)
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