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Deficiency of interleukin-1 receptor antagonist causes spontaneous femoral artery aneurysms

Kikuo Isoda¹, Tomiharu Niida¹, Harumi Kondo¹ & Fumikaka Ohsuzu¹

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1. National Defense Medical College, Internal Medicine 1

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Document Type:

Manuscript

Date:

Received 28 January 2009 15:07 UTC; Posted 29 January 2009

Subjects:

Molecular Cell Biology

Tags:

• cytokines,
• aneurysm,
• INFLAMMATION,
• immunity

Abstract:

Interleukin (IL) -1, a proinflammatory cytokine, increases in aneurysm, and the IL-1 receptor antagonist (IL-1Ra) modulates IL-1 activity endogenously. We show here that IL-1Ra-deficiency in hematopoietic cells disrupts immune system homeostasis and causes spontaneous femoral artery aneurysms in mice lacking interventions such as drugs or surgery. Thus, IL-1Ra-deficient mice provide easy observations with age and diminish mortality that typically follows surgical procedures. Furthermore, since IL-1Ra-deficient mice contain the entire spectrum of lesions observed during inflammatory aneurysm, this mouse model likely will provide numerous opportunities to study the pathogenesis and therapy of inflammatory aneurysm.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Isoda, Kikuo, Niida, Tomiharu, Kondo, Harumi, and Ohsuzu, Fumikaka. Deficiency of interleukin-1 receptor antagonist causes spontaneous femoral artery aneurysms. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.2826.1> (2009)

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