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Polyethylenimine-Modified Multiwalled Carbon Nanotubes for Plasmid DNA Gene Delivery

Bo-Zhang Yu¹, Ji-Fei Ma¹ & Wen-Xin Li¹

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1. Chinese Academy of Sciences, Shanghai Institute of Applied Physics

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Document Type:

Manuscript

Date:

Received 05 January 2009 07:22 UTC; Posted 07 January 2009

Subjects:

Biotechnology, Cancer, Chemistry

Tags:

• high-molecular-weight PEI
• modified multiwalled carbon nanotubes
• plasmid DNA
• green fluorescent protein
• cytotoxicity
• techniques
• gene delivery
• Polyethylenimine

Abstract:

An efficient molecular delivery technique based on the transporting high-molecular-weight PEI 600K-modified multiwalled carbon nanotubes (PEI 600K-MWCNTs) into cell membranes is reported. The PEI 600K-MWCNTs exhibit low cytotoxicity and its associated plasmid DNA (pDNA) is delivered to cells efficiently, and the green fluorescent protein (GFP) levels up to 18 times higher than that of naked DNA were observed.

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License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Yu, Bo-Zhang , Ma, Ji-Fei, and Li, Wen-Xin. Polyethylenimine-Modified Multiwalled Carbon Nanotubes for Plasmid DNA Gene Delivery. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2009.2753.1> (2009)

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