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Specificity and Evolvability in Eukaryotic Protein Interaction Networks

Pedro Beltrao¹

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1. EMBL-Heidelberg

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Date:

Received 28 February 2007 20:11 UTC; Posted 02 March 2007

Subjects:

Bioinformatics, Evolutionary Biology

Tags:

• networks
• specificity
• evolvability

Abstract:

Progress in uncovering the protein interaction networks of several species has led to questions of what underlying principles might govern their organization. Few studies have tried to determine the impact of protein interaction network evolution on the observed physiological differences between species. Using comparative genomics and structural information, we show here that eukaryotic species have rewired their interactomes at a fast rate of approximately 10?5 interactions changed per protein pair, per million years of divergence. For Homo sapiens this corresponds to 103 interactions changed per million years. Additionally we find that the specificity of binding strongly determines the interaction turnover and that different biological processes show significantly different link dynamics. In particular, human proteins involved in immune response, transport, and establishment of localization show signs of positive selection for change of interactions. Our analysis suggests that a small degree of molecular divergence can give rise to important changes at the network level. We propose that the power law distribution observed in protein interaction networks could be partly explained by the cell’s requirement for different degrees of protein binding specificity.

Presented at:

Interactome Networks (short talk), 30 August 2006

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This document is licensed to the public under the Creative Commons Attribution 2.5 License

How to cite this document:

Beltrao, Pedro. Specificity and Evolvability in Eukaryotic Protein Interaction Networks . Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2007.26.1> (2007)

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