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Hemodynamic and electrophysiological evidence of resting-state network activity in the primate

Allen Ardestani¹, Wei Shen¹, Felix Darvas², Arthur Toga³ & Joaquin Fuster¹

Correspondence: (Login to view email address)

1. Semel Institute for Neuroscience and Human Behavior, UCLA
2. Department of Neurological Surgery, University of Washington
3. Laboratory of Neuroimaging, Department of Neurology, UCLA

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Document Type:

Poster

Date:

Received 25 November 2008 00:59 UTC; Posted 25 November 2008

Subjects:

Neuroscience

Tags:

• resting state
• monkey
• network
• oscillation
• NIRS
• Gamma
• coherence

Abstract:

An expanding body of literature describes the existence of concerted brain activations in the absence of any external stimuli. Resting-state networks have been identified and demonstrated to be modulated during the performance of specific cognitive operations. However, despite mounting evidence the possibility still remains that those correlated signal fluctuations reflect non-neural phenomena. In order to isolate functionally relevant spontaneous coactivations, we utilized a multi-level sampling approach to obtain co-registered brain signals across a range of sampling resolution and sensitivity. Surface and local field potentials, hemodynamic signals (near-infrared spectroscopy, NIRS), and cell spiking were recorded from dorsolateral prefrontal and posterior parietal cortices in four monkeys trained to remain motionless in a primate chair. The use of an optical recording technique (NIRS) allows measurement of a signal that is physiologically equivalent to that obtained using BOLD fMRI, though with millisecond temporal resolution and minimal technical or environmental constraints. The different signal types exhibited correlations between the two regions of interest in both the frequency and time domains. This evidence suggests that the resting-state network activations detected by fMRI do in fact reflect functional coactivations of areas across multiple levels of network communication.

Presented at:

38th Annual Meeting of the Society for Neuroscience, 16 November 2008

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Ardestani, Allen, Shen, Wei, Darvas, Felix, Toga, Arthur, and Fuster, Joaquin. Hemodynamic and electrophysiological evidence of resting-state network activity in the primate. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2008.2562.1> (2008)

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