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A population-based study of glutathione-S-transferase M1, T1 and P1 genotypes

Monika Sivoňová¹, Iveta Waczulíková², Dušan Dobrota¹, Tatiana Matáková¹, Jozef Hatok¹, Peter Račay¹ & Ján Kliment¹

Correspondence: (Login to view email address)

1. Jessenius School of Medicine
2. Faculty of Mathematics, Physics, and Informatics

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Document Type:

Manuscript

Date:

Received 24 November 2008 07:11 UTC; Posted 24 November 2008

Subjects:

Cancer, Genetics & Genomics

Tags:

• glutathione-S-transferase
• prostate cancer
• Slovak population
• polymorphism
• genotype

Abstract:

A retrospective study on healthy, unrelated subjects was conducted in order to estimate population glutathione-S-transferases (GST) genotype frequencies in Slovak population of men and compare our results with already published data (GSEC project)¹. A further aim of the study was to evaluate frequencies of the GST polymorphisms also in patients with prostate cancer in order to compare the evaluated proportions with those found in the control subjects. Analysis for the GST gene polymorphisms was performed by PCR and PCR-RFLP. We found that the proportions are not significantly different from those estimated in a European multicentre study or from the results published by another group in Slovakia. We found significantly increased age-standardized prostate cancer prevalence rates in the carriers of GSTM1 null genotype (P = 0.037) and trend for such an increase in the carriers of GSTP1 polymorphism when compared with the respective groups of non-carriers. Because understanding of the contribution of GST gene polymorphisms and their interactions with other relevant factors may improve screening diagnostic assays for prostate cancer, we discuss issues of study feasibility, study design, and statistical power, which should be taken into account in planning further trials.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Sivoňová, Monika, Waczulíková, Iveta, Dobrota, Dušan, Matáková, Tatiana, Hatok, Jozef, Račay, Peter, and Kliment, Ján. A population-based study of glutathione-S-transferase M1, T1 and P1 genotypes . Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.2559.1> (2008)

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