1 vote

Predictive Models of Insulin Resistance Derived from Simple Morphometric and Metabolic Measurements Related to Obesity in Baboons.

Alberto Chavez¹, Amalia Gastaldelli², Juan Carlos Lopez-Alvarenga³, Rodolfo Guardado-Mendoza¹, Michelle Leland⁴, M. Elizabeth Tejero⁵, GianPio Sorice¹, Alberto Davalli⁶, Raul Bastarrachea⁷, Anthony Comuzzie⁸, Ralph DeFronzo⁹ & Franco Folli¹⁰

Correspondence: (Login to view email address)

1. University of Texas Health Science Center at San Antonio, Medicine
2. Institute of Clinical Physiology-National Research Council,
3. Southwest Foundation for Biomedical Research, Genetics
4. University of Texas Health Science Center at San Antonio, Lab Animal Resources
5. Southwest Foundation for Biomedical Research / Southwest National Primate Research Center, Genetics
6. Istituto Scientifico San Raffaele,
7. Univ Texas, San Antonio,
8. Southwest Foundation for Biomedical Research,
9. UTHSCSA, Medicine
10. University of Texas Health Science Center at San Antonio, San Antonio, Texas, Diabetes

PDF (265.1 KB)

Document Type:

Manuscript

Date:

Received 22 October 2008 14:53 UTC; Posted 24 October 2008

Subjects:

Pharmacology

Tags:

• Insulin-Resistance
• Predictive-Models
• Type 2 diabetes
• Non-Human Primates
• Obesity

Abstract:

Non-human primates are valuable models for the study of insulin resistance and human obesity. In baboons, insulin sensitivity levels can be evaluated directly with the euglycemic clamp and is highly predicted by adiposity, metabolic markers of obesity and impaired glucose metabolism (i.e. percent body fat by DXA and hemoglobin A1C). However, a simple method to screen and identify obese insulin resistant baboons for inclusion in interventional studies is not available. We characterized a population of obese nondiabetic, insulin resistant baboons using the euglycemic clamp technique and used a multivariate linear regression analysis (after adjustment for gender) to test three different predictive models for insulin sensitivity. In the first model, abdominal circumference explained 63% of insulin mediated glucose uptake. The second model, which included fasting plasma insulin (log transformed) and abdominal circumference, explained 69% of insulin-stimulated glucose uptake. The third model, which contained abdominal circumference and 1/log (FPI+FPG), explained 70% of insulin sensitivity. In baboons, simple morphometric measurements of adiposity/obesity, i.e. abdominal circumference, plus baseline markers of glucose metabolism, i.e. fasting plasma glucose and insulin, provide a feasible method to screen and identify overweight/obese insulin resistant baboons for inclusion interventional studies aimed to study human obesity and type 2 diabetes.

Discussion

Votes:

1 vote

(Login to vote)

Comments:

0 comments

(Login to post a comment)

Share:

(Login to share with a colleague)

Additional information

License:

This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Chavez, Alberto, Gastaldelli, Amalia, Lopez-Alvarenga, Juan Carlos, Guardado-Mendoza, Rodolfo, Leland, Michelle, Tejero, M. Elizabeth, Sorice, GianPio, Davalli, Alberto, Bastarrachea, Raul, Comuzzie, Anthony, DeFronzo, Ralph, and Folli, Franco. Predictive Models of Insulin Resistance Derived from Simple Morphometric and Metabolic Measurements Related to Obesity in Baboons.. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.2429.1> (2008)

Version info:

Other versions of this document in Nature Precedings

None.

Other versions of this document elsewhere on the web

None known.

Submit a new version link