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Steroidal anti inflammatory drug betamethasone significantly alters level of striatal dopamine in a rat model of Parkinson’s disease

Mehdi Shafiee Ardestani¹, Hasan Mehrab², Amin Geravand², Nasir Mohajer³ & Mostafa Saffari⁴

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1. Department of Medicinal Chemistry & Radiopharmacy, TUMS, Tehran, Iran
2. Department of Pharmacoloy, Faculty of Pharmacy, Jondishapour University of Medical Sciences, Ahwaz, Iran
3. Department of Pharmaceutics, Faculty of Pharmacy, TUMS, Tehran, Iran
4. Department of Pharmaceutics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Date:

Received 25 September 2008 20:10 UTC; Posted 26 September 2008

Subjects:

Chemistry, Immunology, Neuroscience, Pharmacology

Tags:

• Parkinson’s Disease
• microdialysis technique
• betamethasone
• glutamate

Abstract:

Many scientific efforts have been well done to investigate the effects of anti inflammatory agents on the degenerative brain diseases such as Parkinson’s (PD) or Alzheimer’s disease and their affiliated sings. Previously we showed the effectiveness of steroids on rigidity of PD and in the study for further mechanistic investigation of that observation the microdialysis technique was employed to determine the striatal dopamine changes in parkinsonian rats after administration of betamethasone (0.12, 0.24 mg/kg) respectively. Our findings showed us the significant increase in the striatal dopaminergic neurotransmission (P<0.05) after administration of betamethasone comparing to the controls. These observations suggest a new mechanism for betamethasone on striatum dopaminergic neurotransmission leading us to gather further evidence about effectiveness of betamethasone in PD.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Shafiee Ardestani, Mehdi, Mehrab, Hasan, Geravand, Amin, Mohajer, Nasir, and Saffari, Mostafa. Steroidal anti inflammatory drug betamethasone significantly alters level of striatal dopamine in a rat model of Parkinson’s disease. Available from Nature Precedings <http://dx.doi.org/10.1038/npre.2008.2330.1> (2008)

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