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Simulations of Antigenic Variability in Influenza A

Nuno Fachada¹, Vitor V. Lopes² & Agostinho C. Rosa¹

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1. Instituto de Sistemas e Robótica, Instituto Superior Técnico
2. INETI - Instituto Nacional de Engenharia, Tecnologia e Inovação

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Document Type:

Manuscript

Date:

Received 15 September 2008 00:15 UTC; Posted 15 September 2008

Subjects:

Immunology, Bioinformatics

Tags:

• Influenza A virus
• agent-based modeling
• immune response
• antigen shift
• antigen drift
• simulations

Abstract:

Computational models of the immune system (IS) and pathogenic agents have several applications, such as theory testing and validation, or as a complement to first stages of drug trials. One possible application is the prediction of the lethality of new Influenza A strains, which are constantly created due to antigenic drift and shift. Here, we present several simulations of antigenic variability in Influenza A using an agent-based approach, where low level molecular antigen-antibody interactions are explicitly described. Antigenic drift and shift events are analyzed regarding the virulence of emergent strains against the IS. Results are discussed from a qualitative point of view taking into account recent and generally recognized immunology and influenza literature.

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This document is licensed to the public under the Creative Commons Attribution 3.0 License

How to cite this document:

Fachada, Nuno, Lopes, Vitor, and Rosa, Agostinho. Simulations of Antigenic Variability in Influenza A. Available from Nature Precedings <http://hdl.handle.net/10101/npre.2008.2303.1> (2008)

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